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    C1ql4 complement component 1, q subcomponent-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 239659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C1ql4provided by MGI
    Official Full Name
    complement component 1, q subcomponent-like 4provided by MGI
    Primary source
    MGI:MGI:3579909
    See related
    Ensembl:ENSMUSG00000001076 AllianceGenome:MGI:3579909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTRP11; C1qtnf11
    Summary
    Enables identical protein binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; liver; and lung. Orthologous to human C1QL4 (complement C1q like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 2.0), whole brain E14.5 (RPKM 1.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1ql4 in Genome Data Viewer
    Location:
    15 F1; 15 55.84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98981967..98988555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99084086..99090674, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E947 Neighboring gene predicted gene, 34284 Neighboring gene trophinin associated protein Neighboring gene microRNA 6960 Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CTRP11 contributes modestly to systemic metabolism and energy balance. Sarver DC, et al. FASEB J, 2022 Jun. PMID 35579659, Free PMC Article
    2. Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion. Hamoud N, et al. Nat Commun, 2018 Oct 26. PMID 30367035, Free PMC Article
    3. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. Wei Z, et al. J Biol Chem, 2013 Apr 12. PMID 23449976, Free PMC Article
    4. Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins. Iijima T, et al. Eur J Neurosci, 2010 May. PMID 20525073
    5. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Bolliger MF, et al. Proc Natl Acad Sci U S A, 2011 Feb 8. PMID 21262840, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTRP11 contributes modestly to systemic metabolism and energy balance.
      Title: CTRP11 contributes modestly to systemic metabolism and energy balance.
    2. The secreted complement C1q-like protein 4 repress myoblast fusion by specifically interacting with G protein-coupled receptor BAI3.
      Title: Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.
    3. These results implicate CTRP11 as a novel secreted regulator of adipogenesis and highlight the potential paracrine cross-talk between adipocytes and cells of the stromal vascular compartment in maintaining adipose tissue homeostasis.
      Title: C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C1q-like protein 4
    Names
    C1q and tumor necrosis factor-related protein 11
    C1q/TNF-related protein 11
    C1qTNF11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024702.1 → NP_001019873.1  complement C1q-like protein 4 precursor

      See identical proteins and their annotated locations for NP_001019873.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ002403
      Consensus CDS
      CCDS27814.1
      UniProtKB/Swiss-Prot
      B2RV40, Q4ZJM9
      Related
      ENSMUSP00000068402.4, ENSMUST00000064462.5
      Conserved Domains (1) summary
      pfam00386
      Location:111 → 235
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98981967..98988555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520975.3 → XP_006521038.1  complement C1q-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006521038.1

      UniProtKB/Swiss-Prot
      B2RV40, Q4ZJM9
      Conserved Domains (1) summary
      pfam00386
      Location:111 → 235
      C1q; C1q domain

    2. XM_030248564.1 → XP_030104424.1  complement C1q-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RV40, Q4ZJM9
      Conserved Domains (1) summary
      pfam00386
      Location:111 → 235
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4ZJM9.1 GenPept UniProtKB/Swiss-Prot:Q4ZJM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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