Marchf2 membrane associated ring-CH-type finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Marchf2provided by MGI
Official Full Name: membrane associated ring-CH-type finger 2provided by MGI
Primary source: MGI:MGI:1925915
See related: Ensembl:ENSMUSG00000079557 AllianceGenome:MGI:1925915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: March2; MARCH-II; 9530046H09Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in antibacterial innate immune response and antiviral innate immune response. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and endoplasmic reticulum. Is expressed in several structures, including axial skeleton; bone; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 31.0), liver E14 (RPKM 27.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (33904666..33937651, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33685692..33718677, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
Title: The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9.
Title: Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9.
Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Markers

March2 (e-PCR), detects polymorphism
- UniSTS:478957

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF2

Names: E3 ubiquitin-protein ligase MARCH2; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RING-type E3 ubiquitin transferase MARCHF2; membrane-associated RING finger protein 2; membrane-associated RING-CH protein II; membrane-associated ring finger (C3HC4) 2

NP_001239409.1

EC 2.3.2.27

NP_663461.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252480.1 → NP_001239409.1 E3 ubiquitin-protein ligase MARCHF2 isoform 2

See identical proteins and their annotated locations for NP_001239409.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK079234, AV336582, CT030732

Consensus CDS

CCDS57064.1

UniProtKB/Swiss-Prot

Q8C4Q5, Q99M02

UniProtKB/TrEMBL

Q8BPS3

Related

ENSMUSP00000134220.2, ENSMUST00000172767.9

Conserved Domains (2) summary

pfam00558
Location:173 → 224

Vpu; Vpu protein

cd16808
Location:62 → 113

RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)
NM_145486.5 → NP_663461.2 E3 ubiquitin-protein ligase MARCHF2 isoform 1

See identical proteins and their annotated locations for NP_663461.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AK039778, AK040163, BF729651, CA324654, CT030732

Consensus CDS

CCDS28627.1

UniProtKB/TrEMBL

Q8BPS3, Q8CA25

Related

ENSMUSP00000065225.7, ENSMUST00000066121.13

Conserved Domains (2) summary

pfam00558
Location:173 → 224

Vpu; Vpu protein

smart00744
Location:63 → 110

RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RNA

NR_045522.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK040163, AK053434, BB634112, CT030732
NR_045523.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an internal exon and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK040163, CT030732

Related

ENSMUST00000172934.8