Ccdc181 coiled-coil domain containing 181 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccdc181provided by MGI
Official Full Name: coiled-coil domain containing 181provided by MGI
Primary source: MGI:MGI:1922145
See related: Ensembl:ENSMUSG00000026578 AllianceGenome:MGI:1922145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930455F23Rik
Summary: Enables microtubule binding activity. Located in manchette and sperm flagellum. Is expressed in 3rd ventricle; 4th ventricle; and choroid invagination. Orthologous to human CCDC181 (coiled-coil domain containing 181). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 47.2), frontal lobe adult (RPKM 5.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.2; 1 71.59 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (164103126..164115416)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (164275598..164287847)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.
Title: CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.
Ccdc181 is a binding partner of Hook1. Ccdc181 localizes to the sperm flagella and to the basal half of motile cilia.
Title: Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.
4930455F23Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in manchette	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coiled-coil domain-containing protein 181

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029115.3 → NP_083391.2 coiled-coil domain-containing protein 181

See identical proteins and their annotated locations for NP_083391.2

Status: VALIDATED

Source sequence(s)

BC048086, BC060044

Consensus CDS

CCDS15434.1

UniProtKB/Swiss-Prot

Q3UF07, Q80ZU5, Q8C631, Q9CUL9

Related

ENSMUSP00000027867.7, ENSMUST00000027867.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

164103126..164115416

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154044.1 → XP_036009937.1 coiled-coil domain-containing protein 181 isoform X1

Conserved Domains (1) summary

pfam17380
Location:298 → 455

DUF5401; Family of unknown function (DUF5401)