Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina3fprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 3Fprovided by MGI
Primary source: MGI:MGI:2182838
See related: Ensembl:ENSMUSG00000066363 AllianceGenome:MGI:2182838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2A1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to bacterium; response to cytokine; and response to peptide hormone. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 2.5), mammary gland adult (RPKM 1.4) and 14 other tissues See more
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Genomic context

Location:: 12 E; 12 53.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (104180803..104187388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (104214544..104221129)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease inhibitor A3F

Names: alpha-1 antiproteinasin; antitrypsin; serpin A3F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033335.3 → NP_001028507.2 serine protease inhibitor A3F

See identical proteins and their annotated locations for NP_001028507.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC142112, AK138954, BC139132

Consensus CDS

CCDS26149.1

UniProtKB/Swiss-Prot

B2RT49, Q80X76

UniProtKB/TrEMBL

Q3UTZ5

Related

ENSMUSP00000098641.2, ENSMUST00000101080.2

Conserved Domains (1) summary

cd02056
Location:40 → 405

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
NM_001168294.1 → NP_001161766.1 serine protease inhibitor A3F

See identical proteins and their annotated locations for NP_001161766.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AC142112, AK138954, AK150157, BC139132

Consensus CDS

CCDS26149.1

UniProtKB/Swiss-Prot

B2RT49, Q80X76

UniProtKB/TrEMBL

Q3UTZ5

Related

ENSMUSP00000113945.2, ENSMUST00000121337.8

Conserved Domains (1) summary

cd02056
Location:40 → 405

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
NM_001168295.1 → NP_001161767.1 serine protease inhibitor A3F

See identical proteins and their annotated locations for NP_001161767.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC142112, AK138954, AK150157, BC139132

Consensus CDS

CCDS26149.1

UniProtKB/Swiss-Prot

B2RT49, Q80X76

UniProtKB/TrEMBL

Q3UTZ5

Related

ENSMUSP00000126520.2, ENSMUST00000167049.8

Conserved Domains (1) summary

cd02056
Location:40 → 405

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...