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    Tmem145 transmembrane protein 145 [ Mus musculus (house mouse) ]

    Gene ID: 330485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem145provided by MGI
    Official Full Name
    transmembrane protein 145provided by MGI
    Primary source
    MGI:MGI:3607779
    See related
    Ensembl:ENSMUSG00000043843 AllianceGenome:MGI:3607779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930076A02Rik
    Summary
    Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TMEM145 (transmembrane protein 145). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 48.9), CNS E18 (RPKM 39.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem145 in Genome Data Viewer
    Location:
    7 A3; 7 13.74 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25004981..25015621)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25305500..25316196)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_18300 Neighboring gene proline rich 19 Neighboring gene multiple EGF-like-domains 8 Neighboring gene cornifelin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article
    2. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    3. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • B930076A02Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 145

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403202.1 → NP_001390131.1  transmembrane protein 145 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156992
      UniProtKB/TrEMBL
      A0A5F8MPQ2
      Related
      ENSMUSP00000159059.2, ENSMUST00000205639.3

    2. NM_001403203.1 → NP_001390132.1  transmembrane protein 145 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156992
      UniProtKB/TrEMBL
      D3YU53, E9PUE6

    3. NM_183311.3 → NP_899134.2  transmembrane protein 145 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156992
      Consensus CDS
      CCDS39837.1
      UniProtKB/TrEMBL
      D3YU53, E9PUE6
      Related
      ENSMUSP00000104046.2, ENSMUST00000108409.2
      Conserved Domains (1) summary
      pfam10192
      Location:157 → 411
      GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

    RNA

    1. NR_175362.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156992

    2. NR_175363.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156992

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25004981..25015621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540114.3 → XP_006540177.1  transmembrane protein 145 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPQ2
      Conserved Domains (2) summary
      PHA03247
      Location:476 → 599
      PHA03247; large tegument protein UL36; Provisional
      pfam10192
      Location:157 → 411
      GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

    2. XM_030242692.2 → XP_030098552.1  transmembrane protein 145 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:179 → 302
      PHA03247; large tegument protein UL36; Provisional
      cl21735
      Location:1 → 114
      Lung_7-TM_R; Lung seven transmembrane receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4U2.1 GenPept UniProtKB/Swiss-Prot:Q8C4U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools