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    APL1 Apl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APL1
    Official Full Name
    Apl1p
    Primary source
    SGD:S000003765
    Locus tag
    YJR005W
    See related
    AllianceGenome:SGD:S000003765; FungiDB:YJR005W; VEuPathDB:YJR005W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YAP80
    Summary
    Predicted to enable clathrin binding activity. Predicted to be involved in vesicle-mediated transport. Located in endocytic vesicle. Part of AP-2 adaptor complex. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1) and AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APL1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (445923..448025)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mrx12p Neighboring gene Sag1p Neighboring gene Lso1p Neighboring gene DNA-directed DNA polymerase delta subunit POL31

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes. Kirchhausen T. Mol Cell Biol, 1990 Nov. PMID 2122239, Free PMC Article
    2. Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. Rad MR, et al. J Cell Sci, 1995 Apr. PMID 7615679
    3. Clathrin Adaptor Complex-interacting Protein Irc6 Functions through the Conserved C-Terminal Domain. Zhou H, et al. Sci Rep, 2019 Mar 14. PMID 30872642, Free PMC Article
    4. Clathrin interactions with C-terminal regions of the yeast AP-1 beta and gamma subunits are important for AP-1 association with clathrin coats. Yeung BG, et al. Traffic, 2001 Aug. PMID 11489214
    5. A systematic approach to identify recycling endocytic cargo depending on the GARP complex. Eising S, et al. Elife, 2019 Jan 29. PMID 30694181, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apl1p
    NP_012538.3
    • Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      445923..448025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181662.3 → NP_012538.3  TPA: Apl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012538.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH9, P27351
      UniProtKB/TrEMBL
      B3LQA3, N1P000
      Conserved Domains (1) summary
      COG5096
      Location:1 → 700
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27351.2

    Gene LinkOut

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