U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SLCO1B7 solute carrier organic anion transporter family member 1B7 (putative) [ Homo sapiens (human) ]

    Gene ID: 338821, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SLCO1B7provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 1B7 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:32934
    See related
    MIM:619875; AllianceGenome:HGNC:32934
    Gene type
    pseudo
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LST3; LST-3; OATP1B7; SLC21A21; LST-3TM12
    Summary
    Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    not in current annotation release
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SLCO1B7 in Genome Data Viewer
    Location:
    12p12.2
    Annotation release Status Assembly Chr Location
    109.20210226 latest, but not current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (21015696..21090106)

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7. Meyer Zu Schwabedissen HE, et al. Pharmacol Res, 2020 Nov. PMID 32818652
    2. OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. Malagnino V, et al. Mol Pharmacol, 2019 Aug. PMID 31127008
    3. LST-3TM12 is a member of the OATP1B family and a functional transporter. Malagnino V, et al. Biochem Pharmacol, 2018 Feb. PMID 29248594
    4. circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis. Ju L, et al. Aging (Albany NY), 2023 Nov 24. PMID 38015711, Free PMC Article
    5. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. Buch S, et al. Gastroenterology, 2010 Dec. PMID 20837016

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.
      Title: circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.
    2. Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
      Title: Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
    3. Results showed that OATP1B3-1B7 interacts with several drugs. One of the identified inhibitors was ezetimibe, which is also a substrate ofOATP1B3-1B7. Moreover, ezetimibe glucuronidation rates were decreased by bromsulphthalein, which is a OATP1B3-1B7 inhibitor. Thus, OATP1B3- 1B7 may function as a smooth endoplasmic reticulum gateway for ezetimibe.
      Title: OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe.
    4. This study investigated the expression and function of LST-3TM12 as a member of a multigene family.
      Title: LST-3TM12 is a member of the OATP1B family and a functional transporter.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh38)

    General gene information

    Go to the top of the page Help

    Markers

    Readthrough SLCO1B3-SLCO1B7

    Readthrough gene: SLCO1B3-SLCO1B7, Included gene: SLCO1B3

    Homology

    Other Names

    • liver-specific organic anion transporter 3
    • liver-specific organic anion transporter 3TM12
    • organic anion transporter LST-3b
    • putative solute carrier organic anion transporter family member 1B7
    • solute carrier organic anion transporter family, member 1B7 (non-functional)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009562.4: Suppressed sequence

      Description
      NM_001009562.4: This RefSeq was removed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V0H7.1 GenPept UniProtKB/Swiss-Prot:G3V0H7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools