INPPL1 inositol polyphosphate phosphatase like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: INPPL1provided by HGNC
Official Full Name: inositol polyphosphate phosphatase like 1provided by HGNC
Primary source: HGNC:HGNC:6080
See related: Ensembl:ENSG00000165458 MIM:600829; AllianceGenome:HGNC:6080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OPSMD; SHIP2
Summary: The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Expression: Ubiquitous expression in placenta (RPKM 19.8), thyroid (RPKM 19.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (72223563..72239147)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (72149924..72165764)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (71935811..71950191)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Helicobacter pylori East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity.
Title: Helicobacter pylori East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity.
Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease pathology progression.
Title: Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease pathology progression.
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
Title: Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Title: PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
OxLDL-stimulated macrophage exosomes promote proatherogenic vascular smooth muscle cell viability and invasion via delivering miR-186-5p then inactivating SHIP2 mediated PI3K/AKT/mTOR pathway.
Title: OxLDL-stimulated macrophage exosomes promote proatherogenic vascular smooth muscle cell viability and invasion via delivering miR-186-5p then inactivating SHIP2 mediated PI3K/AKT/mTOR pathway.
An auxiliary binding interface of SHIP2-SH2 for Y292-phosphorylated FcgammaRIIB reveals diverse recognition mechanisms for tyrosine-phosphorylated receptors involved in different cell signaling pathways.
Title: An auxiliary binding interface of SHIP2-SH2 for Y292-phosphorylated FcγRIIB reveals diverse recognition mechanisms for tyrosine-phosphorylated receptors involved in different cell signaling pathways.
SHIP2 inhibition alters redox-induced PI3K/AKT and MAP kinase pathways via PTEN over-activation in cervical cancer cells.
Title: SHIP2 inhibition alters redox-induced PI3K/AKT and MAP kinase pathways via PTEN over-activation in cervical cancer cells.
IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
Title: IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.
Title: A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.
Expression, purification and characterization of the RhoA-binding domain of human SHIP2 in E.coli.
Title: Expression, purification and characterization of the RhoA-binding domain of human SHIP2 in E.coli.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Opsismodysplasia MedGen: C0432219 OMIM: 258480 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH67903 (e-PCR)
- UniSTS:79363

INPPL1 (e-PCR)
- UniSTS:40458

INPPL1__6468 (e-PCR)
- UniSTS:464501

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables inositol-polyphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol biosynthetic process	TAS Traceable Author Statement more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in ruffle assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

Names: 51C protein; INPPL-1; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2; protein 51C

NP_001558.3

EC 3.1.3.86

XP_005274036.1

EC 3.1.3.86

XP_011543301.1

EC 3.1.3.86

XP_047282843.1

EC 3.1.3.86

XP_047282844.1

EC 3.1.3.86

XP_047282845.1

EC 3.1.3.86

XP_047282846.1

EC 3.1.3.86

XP_047282847.1

EC 3.1.3.86

XP_047282848.1

EC 3.1.3.86

XP_047282849.1

EC 3.1.3.86

XP_054224654.1

EC 3.1.3.86

XP_054224655.1

EC 3.1.3.86

XP_054224656.1

EC 3.1.3.86

XP_054224657.1

EC 3.1.3.86

XP_054224658.1

EC 3.1.3.86

XP_054224659.1

EC 3.1.3.86

XP_054224660.1

EC 3.1.3.86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023253.2 RefSeqGene

Range

4930..19310

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001567.4 → NP_001558.3 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

See identical proteins and their annotated locations for NP_001558.3

Status: REVIEWED

Source sequence(s)

AP000593, BC140853, BG236320, Y14385

Consensus CDS

CCDS8213.1

UniProtKB/Swiss-Prot

B2RTX5, O15357, Q13577, Q13578

Related

ENSP00000298229.2, ENST00000298229.7

Conserved Domains (4) summary

cd09491
Location:1194 → 1256

SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins

cd09101
Location:424 → 727

INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins

smart00454
Location:1202 → 1258

SAM; Sterile alpha motif

cd10343
Location:17 → 119

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

72223563..72239147

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426888.1 → XP_047282844.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1
XM_047426890.1 → XP_047282846.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

UniProtKB/Swiss-Prot

B2RTX5, O15357, Q13577, Q13578
XM_047426887.1 → XP_047282843.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1
XM_005273979.5 → XP_005274036.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

See identical proteins and their annotated locations for XP_005274036.1

Conserved Domains (4) summary

cd09491
Location:1216 → 1278

SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins

cd09101
Location:446 → 749

INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins

smart00454
Location:1224 → 1280

SAM; Sterile alpha motif

cd10343
Location:17 → 119

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
XM_047426891.1 → XP_047282847.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3
XM_011544999.3 → XP_011543301.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

See identical proteins and their annotated locations for XP_011543301.1

UniProtKB/Swiss-Prot

B2RTX5, O15357, Q13577, Q13578

Conserved Domains (4) summary

cd09491
Location:1194 → 1256

SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins

cd09101
Location:424 → 727

INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins

smart00454
Location:1202 → 1258

SAM; Sterile alpha motif

cd10343
Location:17 → 119

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
XM_047426892.1 → XP_047282848.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4
XM_047426889.1 → XP_047282845.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1
XM_047426893.1 → XP_047282849.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5

Related

ENSP00000444619.1, ENST00000538751.5

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

72149924..72165764

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054368682.1 → XP_054224657.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2
XM_054368679.1 → XP_054224654.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1
XM_054368683.1 → XP_054224658.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3
XM_054368681.1 → XP_054224656.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2
XM_054368684.1 → XP_054224659.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4
XM_054368680.1 → XP_054224655.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1
XM_054368685.1 → XP_054224660.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5