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    ORAI2 ORAI calcium release-activated calcium modulator 2 [ Homo sapiens (human) ]

    Gene ID: 80228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ORAI2provided by HGNC
    Official Full Name
    ORAI calcium release-activated calcium modulator 2provided by HGNC
    Primary source
    HGNC:HGNC:21667
    See related
    Ensembl:ENSG00000160991 MIM:610929; AllianceGenome:HGNC:21667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBCIP2; C7orf19; MEM142B; TMEM142B
    Summary
    Enables store-operated calcium channel activity. Involved in store-operated calcium entry. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen (RPKM 5.4), bone marrow (RPKM 5.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ORAI2 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102433575..102456825)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103751220..103774454)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102074022..102097272)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100289561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18502 Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18503 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102036787-102037328 Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC105375433 Neighboring gene microRNA 548o Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26431 Neighboring gene NANOG hESC enhancer GRCh37_chr7:102061269-102061799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102066011-102066914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26433 Neighboring gene Sharpr-MPRA regulatory region 9959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102086939-102087486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102095159-102095659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102105053-102105702 Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102105832-102106358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102106359-102106884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26437 Neighboring gene microRNA 5090 Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly. Wu S, et al. Cancer Res, 2021 Feb 15. PMID 33310726
    2. Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses. Yuan F, et al. Dis Markers, 2019. PMID 31772693, Free PMC Article
    3. Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling. Singh AK, et al. Life Sci, 2020 Nov 15. PMID 32882268
    4. ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells. Scremin E, et al. Int J Mol Sci, 2020 Jul 25. PMID 32722509, Free PMC Article
    5. Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue. Ma Y, et al. Nat Commun, 2021 Dec 2. PMID 34857756, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
      Title: Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
    2. Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
      Title: Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
    3. ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly.
      Title: ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly.
    4. ORAI2 Down-Regulation Potentiates SOCE and Decreases Abeta42 Accumulation in Human Neuroglioma Cells.
      Title: ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells.
    5. Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-kappaB signalling.
      Title: Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling.
    6. Higher expression of Orai2 was independently associated with a worse prognosis of patients with the classical and mesenchymal subtypes of glioblastoma.A strong association between Orai2 expression and apoptosis, stemness, and an epithelial-mesenchymal transition in the glioblastoma.
      Title: Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses.
    7. ORAI1-3, are preferentially expressed in proximal tubular epithelial cells and downregulated in patients with diabetic nephropathy.
      Title: ORAI channels are critical for receptor-mediated endocytosis of albumin.
    8. findings provide evidence for a role for Orai1 and Orai2, in SOCE and migration in the human HL60 promyeloblastic cell line
      Title: Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation.
    9. results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
      Title: A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
    10. Orai1, Orai2 and STIM1 form functional Ca(2+) release-activated Ca(2+) channels in OUMS-27 cells (chondrocytes) and that these complexes are responsible for sustained Ca(2+) entry in response to agonist stimulation.
      Title: Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12474, FLJ14733, FLJ44818

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables store-operated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables store-operated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in store-operated calcium entry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein orai-2
    Names
    CAP-binding protein complex interacting protein 2
    H_NH0514P08.8
    putative protein ORAI2-2
    transmembrane protein 142B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126340.3 → NP_001119812.1  protein orai-2 isoform a

      See identical proteins and their annotated locations for NP_001119812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC093668, HY064081
      Consensus CDS
      CCDS5722.1
      UniProtKB/Swiss-Prot
      Q6IA68, Q8WY94, Q96SN7, Q9H9Y3
      UniProtKB/TrEMBL
      C9JQR7
      Related
      ENSP00000420178.2, ENST00000495936.7
      Conserved Domains (1) summary
      pfam07856
      Location:47 → 228
      Orai-1; Mediator of CRAC channel activity

    2. NM_001271818.2 → NP_001258747.1  protein orai-2 isoform a

      See identical proteins and their annotated locations for NP_001258747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC093668, CN366874, HY064081
      Consensus CDS
      CCDS5722.1
      UniProtKB/Swiss-Prot
      Q6IA68, Q8WY94, Q96SN7, Q9H9Y3
      UniProtKB/TrEMBL
      C9JQR7
      Related
      ENSP00000348752.2, ENST00000356387.6
      Conserved Domains (1) summary
      pfam07856
      Location:47 → 228
      Orai-1; Mediator of CRAC channel activity

    3. NM_001271819.2 → NP_001258748.1  protein orai-2 isoform b

      See identical proteins and their annotated locations for NP_001258748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon in the 5' UTR compared to variant 3, initiating translation at an alternate downstream in-frame start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC093668, DC384892, HY064081
      UniProtKB/TrEMBL
      B4DUB4
      Conserved Domains (1) summary
      pfam07856
      Location:1 → 151
      Orai-1; Mediator of CRAC channel activity

    4. NM_032831.4 → NP_116220.1  protein orai-2 isoform a

      See identical proteins and their annotated locations for NP_116220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC093668, AK027639, HY064081
      Consensus CDS
      CCDS5722.1
      UniProtKB/Swiss-Prot
      Q6IA68, Q8WY94, Q96SN7, Q9H9Y3
      UniProtKB/TrEMBL
      C9JQR7
      Related
      ENSP00000385489.3, ENST00000403646.8
      Conserved Domains (1) summary
      pfam07856
      Location:47 → 228
      Orai-1; Mediator of CRAC channel activity

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      102433575..102456825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      103751220..103774454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96SN7.1 GenPept UniProtKB/Swiss-Prot:Q96SN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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