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    UBE2S ubiquitin conjugating enzyme E2 S [ Homo sapiens (human) ]

    Gene ID: 27338, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UBE2Sprovided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Sprovided by HGNC
    Primary source
    HGNC:HGNC:17895
    See related
    Ensembl:ENSG00000108106 MIM:610309; AllianceGenome:HGNC:17895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EPF5; E2EPF; E2-EPF
    Summary
    This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UBE2S in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55399745..55407788, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58495197..58503241, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55911113..55919156, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55890663-55891163 Neighboring gene transmembrane protein 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55895260-55896222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15093 Neighboring gene ribosomal protein L28 Neighboring gene microRNA 6805 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55915190-55915690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55915691-55916191 Neighboring gene small nucleolar RNA, C/D box 157 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:55918619-55919132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11031 Neighboring gene Sharpr-MPRA regulatory region 8373 Neighboring gene uncharacterized LOC105372462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55930479-55931048 Neighboring gene MPRA-validated peak3567 silencer Neighboring gene shisa family member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55953359-55953987

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. Liu Z, et al. J Biol Chem, 1992 Aug 5. PMID 1379239
    2. Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development. Wang P, et al. J Invest Dermatol, 2021 Feb. PMID 32603752
    3. Ube2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer. Qin Y, et al. Int J Med Sci, 2020. PMID 32038111, Free PMC Article
    4. UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway. Hu W, et al. J Ovarian Res, 2021 Sep 17. PMID 34535173, Free PMC Article
    5. UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells. Liu Z, et al. BMB Rep, 2018 Dec. PMID 30545437, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [High expression of UBE2S promotes progression of hepatocellular carcinoma by increasing cancer cell stemness].
      Title: [High expression of UBE2S promotes progression of hepatocellular carcinoma by increasing cancer cell stemness].
    2. As a potential predictor of pan-cancer, UBE2S is related to tumor-associated macrophage infiltration.
      Title: As a potential predictor of pan-cancer, UBE2S is related to tumor-associated macrophage infiltration.
    3. UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
      Title: UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
    4. Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway.
      Title: Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway.
    5. UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis.
      Title: UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis.
    6. UBE2S as a novel ubiquitinated regulator of p16 and beta-catenin to promote bone metastasis of prostate cancer.
      Title: UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer.
    7. UBE2S activates NF-kappaB signaling by binding with IkappaBalpha and promotes metastasis of lung adenocarcinoma cells.
      Title: UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells.
    8. UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
      Title: UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
    9. Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.
      Title: Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.
    10. UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
      Title: UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables anaphase-promoting complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exit from mitosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in free ubiquitin chain polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K27-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K29-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K6-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 S
    Names
    E2 ubiquitin-conjugating enzyme S
    E2-EPF5
    ubiquitin carrier protein S
    ubiquitin conjugating enzyme E2S
    ubiquitin-conjugating enzyme E2-24 kDa
    ubiquitin-conjugating enzyme E2-EPF5
    ubiquitin-protein ligase S
    NP_055316.2
    XP_011525054.1
    XP_054176554.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014501.3 → NP_055316.2  ubiquitin-conjugating enzyme E2 S

      See identical proteins and their annotated locations for NP_055316.2

      Status: REVIEWED

      Source sequence(s)
      AC020922, BC065364, CA421746, CN305224
      Consensus CDS
      CCDS33114.1
      UniProtKB/Swiss-Prot
      Q16763, Q9BTC1
      UniProtKB/TrEMBL
      Q2QD04, Q6NXQ4
      Related
      ENSP00000264552.8, ENST00000264552.14
      Conserved Domains (1) summary
      pfam00179
      Location:16 → 152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55399745..55407788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526752.3 → XP_011525054.1  ubiquitin-conjugating enzyme E2 S isoform X1

      Conserved Domains (1) summary
      pfam00179
      Location:16 → 114
      UQ_con; Ubiquitin-conjugating enzyme

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58495197..58503241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320579.1 → XP_054176554.1  ubiquitin-conjugating enzyme E2 S isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16763.2 GenPept UniProtKB/Swiss-Prot:Q16763

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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