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    Trit1 tRNA isopentenyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66966, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trit1provided by MGI
    Official Full Name
    tRNA isopentenyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1914216
    See related
    Ensembl:ENSMUSG00000028653 AllianceGenome:MGI:1914216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IPT; IPPT; MOD5; 2310075G14Rik
    Summary
    Enables tRNA dimethylallyltransferase activity. Involved in tRNA modification. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.3), CNS E14 (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trit1 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122910342..122948742)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123016544..123054949)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene STARR-positive B cell enhancer ABC_E7983 Neighboring gene predicted gene, 54255 Neighboring gene STARR-positive B cell enhancer ABC_E11253 Neighboring gene v-myc avian myelocytomatosis viral oncogene lung carcinoma derived Neighboring gene STARR-positive B cell enhancer ABC_E2710 Neighboring gene STARR-positive B cell enhancer ABC_E3511 Neighboring gene STARR-positive B cell enhancer ABC_E4662 Neighboring gene STARR-positive B cell enhancer ABC_E4663 Neighboring gene predicted gene 12923 Neighboring gene predicted gene, 46868 Neighboring gene bone morphogenetic protein 8b Neighboring gene predicted gene, 17244 Neighboring gene 3-oxoacid CoA transferase 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian Trit1 is a tRNA([Ser]Sec)-isopentenyl transferase required for full selenoprotein expression. Fradejas N, et al. Biochem J, 2013 Mar 1. PMID 23289710
    2. The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression. Fradejas-Villar N, et al. Int J Mol Sci, 2021 Oct 23. PMID 34768885, Free PMC Article
    3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression.
      Title: The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression.
    2. Knockdown of Trit1 reduces expression of selenoproteins.
      Title: Mammalian Trit1 is a tRNA([Ser]Sec)-isopentenyl transferase required for full selenoprotein expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dimethylallyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dimethylallyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA dimethylallyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA dimethylallyltransferase
    Names
    IPP transferase
    IPTase
    isopentenyl-diphosphate:tRNA isopentenyltransferase
    tRNA dimethylallyltransferase, mitochondrial
    tRNA isopentenyltransferase, mitochondrial
    NP_080149.2
    XP_017175848.1
    XP_036020248.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025873.3 → NP_080149.2  tRNA dimethylallyltransferase precursor

      See identical proteins and their annotated locations for NP_080149.2

      Status: VALIDATED

      Source sequence(s)
      AK003556, AL606906
      Consensus CDS
      CCDS18607.1
      UniProtKB/Swiss-Prot
      B1ARS6, Q80UN9, Q9D1H5
      Related
      ENSMUSP00000099709.4, ENSMUST00000102649.4
      Conserved Domains (3) summary
      PLN02748
      Location:17 → 419
      PLN02748; tRNA dimethylallyltransferase
      COG0324
      Location:24 → 333
      MiaA; tRNA A37 N6-isopentenylltransferase MiaA [Translation, ribosomal structure and biogenesis]
      pfam12171
      Location:395 → 419
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RNA

    1. NR_151450.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK003556, AK010176, AL606906
      Related
      ENSMUST00000147165.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      122910342..122948742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164355.1 → XP_036020248.1  tRNA dimethylallyltransferase isoform X1

      Conserved Domains (2) summary
      pfam12171
      Location:310 → 334
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl40481
      Location:24 → 248
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    2. XM_017320359.3 → XP_017175848.1  tRNA dimethylallyltransferase isoform X2

      Conserved Domains (2) summary
      pfam12171
      Location:168 → 192
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam01715
      Location:7 → 105
      IPPT; IPP transferase

    RNA

    1. XR_003954996.2 RNA Sequence

    2. XR_376340.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UN9.2 GenPept UniProtKB/Swiss-Prot:Q80UN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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