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    Cutal cutA divalent cation tolerance homolog-like [ Mus musculus (house mouse) ]

    Gene ID: 77996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cutalprovided by MGI
    Official Full Name
    cutA divalent cation tolerance homolog-likeprovided by MGI
    Primary source
    MGI:MGI:1925246
    See related
    Ensembl:ENSMUSG00000026870 AllianceGenome:MGI:1925246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D730039F16Rik
    Summary
    Predicted to enable copper ion binding activity. Is expressed in renal cortex. Orthologous to human CUTALP (cutA divalent cation tolerance like, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 20.4), colon adult (RPKM 20.1) and 9 other tissues See more
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    Genomic context

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    See Cutal in Genome Data Viewer
    Location:
    2 B; 2 23.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34764408..34782145)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34874396..34892133)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene STARR-seq mESC enhancer starr_04269 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Neighboring gene STARR-positive B cell enhancer ABC_E3369 Neighboring gene PHD finger protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E1003 Neighboring gene predicted gene, 24905

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cutA divalent cation tolerance homolog-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308024.1 → NP_001294953.1  cutA divalent cation tolerance homolog-like isoform 2

      See identical proteins and their annotated locations for NP_001294953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK033810, AK085616
      Consensus CDS
      CCDS79783.1
      UniProtKB/TrEMBL
      A0A0J9YUN0
      Related
      ENSMUSP00000144258.2, ENSMUST00000028228.6
      Conserved Domains (1) summary
      pfam03091
      Location:54 → 107
      CutA1; CutA1 divalent ion tolerance protein

    2. NM_030021.3 → NP_084297.1  cutA divalent cation tolerance homolog-like isoform 1

      See identical proteins and their annotated locations for NP_084297.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK033810, AK085616
      Consensus CDS
      CCDS15954.1
      UniProtKB/TrEMBL
      Q9D1U5
      Related
      ENSMUSP00000108691.3, ENSMUST00000113068.9
      Conserved Domains (1) summary
      pfam03091
      Location:54 → 151
      CutA1; CutA1 divalent ion tolerance protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34764408..34782145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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