Synj1 synaptojanin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Synj1provided by MGI
Official Full Name: synaptojanin 1provided by MGI
Primary source: MGI:MGI:1354961
See related: Ensembl:ENSMUSG00000022973 AllianceGenome:MGI:1354961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0910; A930006D20Rik
Summary: Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization and synaptic vesicle uncoating. Acts upstream of or within several processes, including phosphatidylinositol dephosphorylation; synaptic vesicle cycle; and synaptic vesicle transport. Part of membrane coat. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 17.6), cortex adult (RPKM 16.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 52.18 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (90732980..90810543, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (90936092..91013727, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons.
Title: Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons.
SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
Title: SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons.
Title: Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons.
These data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in Alzheimer's disease.
Title: Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.
Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
Title: Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.
Title: Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.
SYNJ1 contributes to memory deficits in the aging hippocampus in all forms of Alzheimer's disease.
Title: Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.
report showing expression, location and isoforms of Synj1 and Synj2 in the small and large intestine and that they might participate in intestinal pathology.
Title: The Synaptojanins in the murine small and large intestine.
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses
Title: Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.
a novel mechanism by which reduction of a PI(4,5)P2-degrading enzyme, synj1, improves amyloid-induced neuropathology and behavior deficits through accelerating cellular Abeta clearance.
Title: Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Synj1 (e-PCR), detects polymorphism
- UniSTS:259150

RH124351 (e-PCR)
- UniSTS:161173

stSG606569 (e-PCR)
- UniSTS:446167

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables EH domain binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate 5-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol phosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endosome organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gliogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle recycling	TAS Traceable Author Statement more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle uncoating	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptic vesicle uncoating	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle uncoating	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of clathrin coat	TAS Traceable Author Statement more info	PubMed
part_of clathrin coat of coated pit	ISO Inferred from Sequence Orthology more info
part_of clathrin coat of coated pit	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of membrane coat	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal bouton	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: synaptojanin-1

Names: synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

NP_001038980.1

EC 3.1.3.36

NP_001157955.1

EC 3.1.3.36

NP_001392321.1

EC 3.1.3.36

NP_001392322.1

EC 3.1.3.36

NP_001392323.1

EC 3.1.3.36

NP_001392324.1

EC 3.1.3.36

NP_001392325.1

EC 3.1.3.36

NP_001392326.1

EC 3.1.3.36

NP_001392328.1

EC 3.1.3.36

NP_001392329.1

EC 3.1.3.36

NP_001392330.1

EC 3.1.3.36

NP_001392331.1

EC 3.1.3.36

NP_001392332.1

EC 3.1.3.36

NP_001392333.1

EC 3.1.3.36

NP_001392334.1

EC 3.1.3.36

NP_001392335.1

EC 3.1.3.36

NP_001392336.1

EC 3.1.3.36

NP_001392337.1

EC 3.1.3.36

NP_001392339.1

EC 3.1.3.36

XP_006522900.1

EC 3.1.3.36

XP_006522909.1

EC 3.1.3.36

XP_011244377.1

EC 3.1.3.36

XP_011244378.1

EC 3.1.3.36

XP_011244379.1

EC 3.1.3.36

XP_011244380.1

EC 3.1.3.36

XP_011244381.1

EC 3.1.3.36

XP_011244382.1

EC 3.1.3.36

XP_011244383.1

EC 3.1.3.36

XP_011244384.1

EC 3.1.3.36

XP_011244385.1

EC 3.1.3.36

XP_011244386.1

EC 3.1.3.36

XP_011244387.1

EC 3.1.3.36

XP_011244389.1

EC 3.1.3.36

XP_011244391.1

EC 3.1.3.36

XP_017172325.1

EC 3.1.3.36

XP_017172326.1

EC 3.1.3.36

XP_017172328.1

EC 3.1.3.36

XP_017172329.1

EC 3.1.3.36

XP_017172330.1

EC 3.1.3.36

XP_030104762.1

EC 3.1.3.36

XP_030104763.1

EC 3.1.3.36

XP_030104765.1

EC 3.1.3.36

XP_030104766.1

EC 3.1.3.36

XP_030104768.1

EC 3.1.3.36

XP_030104769.1

EC 3.1.3.36

XP_030104770.1

EC 3.1.3.36

XP_036015603.1

EC 3.1.3.36

XP_036015605.1

EC 3.1.3.36

XP_036015606.1

EC 3.1.3.36

XP_036015610.1

EC 3.1.3.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045515.2 → NP_001038980.1 synaptojanin-1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and includes an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (b) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AC134560, AC141885

Consensus CDS

CCDS49906.1

UniProtKB/TrEMBL

E9Q7S0, F7BQW7

Related

ENSMUSP00000128997.2, ENSMUST00000170853.8

Conserved Domains (3) summary

cd09098
Location:533 → 868

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

pfam02383
Location:60 → 340

Syja_N; SacI homology domain

cl17169
Location:867 → 1008

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001164483.2 → NP_001157955.1 synaptojanin-1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC134560, AC141885

Consensus CDS

CCDS49907.1

UniProtKB/Swiss-Prot

Q8CHC4

UniProtKB/TrEMBL

D3Z656

Related

ENSMUSP00000113308.2, ENSMUST00000121759.8

Conserved Domains (3) summary

cd09098
Location:573 → 908

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

pfam02383
Location:100 → 380

Syja_N; SacI homology domain

cl17169
Location:907 → 1048

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001405392.1 → NP_001392321.1 synaptojanin-1 isoform c

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405393.1 → NP_001392322.1 synaptojanin-1 isoform d

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405394.1 → NP_001392323.1 synaptojanin-1 isoform e

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405395.1 → NP_001392324.1 synaptojanin-1 isoform f

Status: VALIDATED

Source sequence(s)

AC134560, AC141885

Related

ENSMUSP00000113518.3, ENSMUST00000118390.10
NM_001405396.1 → NP_001392325.1 synaptojanin-1 isoform g

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405397.1 → NP_001392326.1 synaptojanin-1 isoform h

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405399.1 → NP_001392328.1 synaptojanin-1 isoform i

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405400.1 → NP_001392329.1 synaptojanin-1 isoform j

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405401.1 → NP_001392330.1 synaptojanin-1 isoform k

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405402.1 → NP_001392331.1 synaptojanin-1 isoform l

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405403.1 → NP_001392332.1 synaptojanin-1 isoform m

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405404.1 → NP_001392333.1 synaptojanin-1 isoform n

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405405.1 → NP_001392334.1 synaptojanin-1 isoform o

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405406.1 → NP_001392335.1 synaptojanin-1 isoform p

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405407.1 → NP_001392336.1 synaptojanin-1 isoform q

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405408.1 → NP_001392337.1 synaptojanin-1 isoform r

Status: VALIDATED

Source sequence(s)

AC134560, AC141885
NM_001405410.1 → NP_001392339.1 synaptojanin-1 isoform s

Status: VALIDATED

Source sequence(s)

AC134560, AC141885

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

90732980..90810543 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248902.2 → XP_030104762.1 synaptojanin-1 isoform X3

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:669 → 1004

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1196 → 1598

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:204 → 624

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1003 → 1144

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036159712.1 → XP_036015605.1 synaptojanin-1 isoform X14

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:677 → 1012

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 624

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1154 → 1544

Atrophin-1; Atrophin-1 family

cl17169
Location:1011 → 1152

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017316840.3 → XP_017172329.1 synaptojanin-1 isoform X37

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:677 → 1012

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 624

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1154 → 1378

Atrophin-1; Atrophin-1 family

cl17169
Location:1011 → 1152

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030248903.2 → XP_030104763.1 synaptojanin-1 isoform X9

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:677 → 1012

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 624

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1154 → 1557

Atrophin-1; Atrophin-1 family

cl17169
Location:1011 → 1152

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017316836.3 → XP_017172325.1 synaptojanin-1 isoform X10

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:677 → 1012

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1204 → 1577

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:204 → 624

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1011 → 1152

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006522837.5 → XP_006522900.1 synaptojanin-1 isoform X6

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:677 → 1012

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 624

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1154 → 1570

Atrophin-1; Atrophin-1 family

cl17169
Location:1011 → 1152

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246082.4 → XP_011244384.1 synaptojanin-1 isoform X15

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:672 → 1007

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1149 → 1539

Atrophin-1; Atrophin-1 family

cl17169
Location:1006 → 1147

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017316841.3 → XP_017172330.1 synaptojanin-1 isoform X38

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:672 → 1007

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1149 → 1373

Atrophin-1; Atrophin-1 family

cl17169
Location:1006 → 1147

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036159710.1 → XP_036015603.1 synaptojanin-1 isoform X11

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:672 → 1007

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1172 → 1552

Atrophin-1; Atrophin-1 family

cl17169
Location:1006 → 1147

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246076.4 → XP_011244378.1 synaptojanin-1 isoform X2

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:672 → 1007

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1199 → 1601

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1006 → 1147

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246081.4 → XP_011244383.1 synaptojanin-1 isoform X13

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1157 → 1547

Atrophin-1; Atrophin-1 family

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030248910.2 → XP_030104770.1 synaptojanin-1 isoform X36

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1157 → 1381

Atrophin-1; Atrophin-1 family

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017316839.3 → XP_017172328.1 synaptojanin-1 isoform X35

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1157 → 1381

Atrophin-1; Atrophin-1 family

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246079.4 → XP_011244381.1 synaptojanin-1 isoform X7

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1157 → 1560

Atrophin-1; Atrophin-1 family

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030248908.2 → XP_030104768.1 synaptojanin-1 isoform X31

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

PRK07764
Location:1200 → 1394

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246077.4 → XP_011244379.1 synaptojanin-1 isoform X4

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1157 → 1576

Atrophin-1; Atrophin-1 family

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246080.4 → XP_011244382.1 synaptojanin-1 isoform X8

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1207 → 1580

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036159717.1 → XP_036015610.1 synaptojanin-1 isoform X33

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1201 → 1424

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030248909.2 → XP_030104769.1 synaptojanin-1 isoform X32

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1201 → 1397

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246078.4 → XP_011244380.1 synaptojanin-1 isoform X5

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1157 → 1573

Atrophin-1; Atrophin-1 family

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246075.4 → XP_011244377.1 synaptojanin-1 isoform X1

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1207 → 1609

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246085.4 → XP_011244387.1 synaptojanin-1 isoform X24

See identical proteins and their annotated locations for XP_011244387.1

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03378
Location:1119 → 1423

PHA03378; EBNA-3B; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017316837.3 → XP_017172326.1 synaptojanin-1 isoform X23

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03378
Location:1119 → 1423

PHA03378; EBNA-3B; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030248905.2 → XP_030104765.1 synaptojanin-1 isoform X18

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:533 → 868

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1060 → 1462

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:60 → 480

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:867 → 1008

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030248906.1 → XP_030104766.1 synaptojanin-1 isoform X20

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:525 → 860

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1052 → 1454

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:60 → 480

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:859 → 1000

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036159713.1 → XP_036015606.1 synaptojanin-1 isoform X21

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:528 → 863

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

COG5329
Location:60 → 483

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam03154
Location:1005 → 1395

Atrophin-1; Atrophin-1 family

cl17169
Location:862 → 1003

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246084.1 → XP_011244386.1 synaptojanin-1 isoform X19

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:528 → 863

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1055 → 1457

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:60 → 483

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:862 → 1003

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246083.1 → XP_011244385.1 synaptojanin-1 isoform X17

UniProtKB/Swiss-Prot

Q8CHC4

Conserved Domains (4) summary

cd09098
Location:536 → 871

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:1063 → 1465

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:60 → 483

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:870 → 1011

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246089.4 → XP_011244391.1 synaptojanin-1 isoform X43

Conserved Domains (4) summary

cd09098
Location:86 → 421

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:607 → 1015

PHA03247; large tegument protein UL36; Provisional

COG5329
Location:2 → 33

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:420 → 561

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006522846.4 → XP_006522909.1 synaptojanin-1 isoform X44

Conserved Domains (3) summary

cd09098
Location:14 → 349

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03247
Location:535 → 943

PHA03247; large tegument protein UL36; Provisional

cl17169
Location:348 → 489

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011246087.4 → XP_011244389.1 synaptojanin-1 isoform X25

UniProtKB/TrEMBL

F7BQW7

Conserved Domains (4) summary

cd09098
Location:680 → 1015

INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1

PHA03378
Location:1119 → 1423

PHA03378; EBNA-3B; Provisional

COG5329
Location:204 → 627

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

cl17169
Location:1014 → 1155

RRM_SF; RNA recognition motif (RRM) superfamily