Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a25provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25provided by MGI
Primary source: MGI:MGI:1915913
See related: Ensembl:ENSMUSG00000026819 AllianceGenome:MGI:1915913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MCSC; SCaMC-2; mKIAA1896; 1110030N17Rik
Summary: Predicted to enable ATP:phosphate antiporter activity. Acts upstream of or within several processes, including response to activity; response to dietary excess; and response to food. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver adult (RPKM 15.8), cerebellum adult (RPKM 9.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32304499..32341482, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32414487..32451470, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that KD feeding induces expression of the muscle circadian gene Slc25a25 via neural pathways, and that SLC25A25 might be involved in muscle thermogenesis under KD-induced hypothermia in mammals.
Title: Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis.
induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress.
Title: Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547045

Slc25a25 (e-PCR), detects polymorphism
- UniSTS:547045

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP:phosphate antiporter activity	ISO Inferred from Sequence Orthology more info
enables ATP:phosphate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ATP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to food	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial adenyl nucleotide antiporter SLC25A25

Names: calcium-binding mitochondrial carrier protein SCaMC-2; mitochondrial Ca2+-dependent solute carrier; short calcium-binding mitochondrial carrier protein 2; small calcium-binding mitochondrial carrier protein 2; solute carrier family 25 member 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164357.1 → NP_001157829.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 2

See identical proteins and their annotated locations for NP_001157829.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AK132204, BB653459, CO043296

Consensus CDS

CCDS50568.1

UniProtKB/Swiss-Prot

A2ASZ8

Related

ENSMUSP00000108936.3, ENSMUST00000113310.9

Conserved Domains (3) summary

cd00051
Location:115 → 174

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00153
Location:309 → 401

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:52 → 109

EF-hand_7; EF-hand domain pair
NM_001164358.1 → NP_001157830.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 3

See identical proteins and their annotated locations for NP_001157830.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

BC066998, CV784232

Consensus CDS

CCDS50567.1

UniProtKB/Swiss-Prot

A2ASZ8

Related

ENSMUSP00000060581.8, ENSMUST00000052119.14

Conserved Domains (4) summary

cd00051
Location:102 → 173

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00153
Location:308 → 400

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:103 → 170

EF-hand_7; EF-hand domain pair

cl08302
Location:63 → 97

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001290558.1 → NP_001277487.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 4

See identical proteins and their annotated locations for NP_001277487.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK049392, BC066998, BY772900

Consensus CDS

CCDS71028.1

UniProtKB/Swiss-Prot

A2ASZ1, A2ASZ5, A2ASZ8, A2ASZ9, Q6NXM8, Q80T78, Q8BHG0, Q8JZT8, Q8VBT4, Q99KD3

Related

ENSMUSP00000108932.3, ENSMUST00000113307.9

Conserved Domains (4) summary

cd00051
Location:82 → 141

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00153
Location:276 → 368

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:83 → 138

EF-hand_7; EF-hand domain pair

cl08302
Location:29 → 77

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001362905.1 → NP_001349834.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 5

Status: VALIDATED

Source sequence(s)

AL928710

Consensus CDS

CCDS89474.1

Related

ENSMUSP00000108933.2, ENSMUST00000113308.8

Conserved Domains (3) summary

cd15897
Location:73 → 97

EFh_PEF; EF-hand motif [structural motif]

cl25352
Location:73 → 159

EFh_PEF; The penta-EF hand (PEF) family

cl28162
Location:211 → 465

Mito_carr; Mitochondrial carrier protein
NM_001362906.1 → NP_001349835.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 6

Status: VALIDATED

Source sequence(s)

AL928710, BM947090

Conserved Domains (5) summary

cd15898
Location:67 → 96

EFh_PI-PLC; EF-hand motif [structural motif]

cd15897
Location:36 → 62

EFh_PEF; EF-hand motif [structural motif]

cl25352
Location:31 → 110

EFh_PEF; The penta-EF hand (PEF) family

cl28162
Location:188 → 442

Mito_carr; Mitochondrial carrier protein

cl28895
Location:67 → 156

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
NM_001362907.1 → NP_001349836.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 7

Status: VALIDATED

Source sequence(s)

AL928710

Conserved Domains (3) summary

cd15897
Location:36 → 62

EFh_PEF; EF-hand motif [structural motif]

cl25352
Location:31 → 124

EFh_PEF; The penta-EF hand (PEF) family

cl28162
Location:176 → 430

Mito_carr; Mitochondrial carrier protein
NM_146118.3 → NP_666230.2 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 1

See identical proteins and their annotated locations for NP_666230.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL928710

Consensus CDS

CCDS15915.1

UniProtKB/Swiss-Prot

A2ASZ8

Related

ENSMUSP00000028160.9, ENSMUST00000028160.15

Conserved Domains (3) summary

cd00051
Location:53 → 110

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00153
Location:321 → 413

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:52 → 109

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

32304499..32341482 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497955.5 → XP_006498018.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X1

Conserved Domains (5) summary

PTZ00169
Location:203 → 457

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

cd15898
Location:82 → 111

EFh_PI-PLC; EF-hand motif [structural motif]

cd15897
Location:53 → 77

EFh_PEF; EF-hand motif [structural motif]

cl28895
Location:82 → 171

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

cl25352
Location:53 → 125

EFh_PEF; The penta-EF hand (PEF) family