Mrm2 mitochondrial rRNA methyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrm2provided by MGI
Official Full Name: mitochondrial rRNA methyltransferase 2provided by MGI
Primary source: MGI:MGI:1915267
See related: Ensembl:ENSMUSG00000029557 AllianceGenome:MGI:1915267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ftsj2; 2310037B18Rik
Summary: Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA methylation and mitochondrial large ribosomal subunit assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 17. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.8), kidney adult (RPKM 5.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 78.94 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (140313429..140317653, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (140327674..140331898, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit.
Title: Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables rRNA (uridine-2'-O-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (uridine-2'-O-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (uridine-2'-O-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial large ribosomal subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial large ribosomal subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in rRNA methylation	NAS Non-traceable Author Statement more info	PubMed
involved_in rRNA processing	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rRNA methyltransferase 2, mitochondrial

Names: 16S rRNA (uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; FtsJ RNA methyltransferase homolog 2; FtsJ homolog 2; protein ftsJ homolog 2; putative ribosomal RNA methyltransferase 2; rRNA (uridine-2'-O-)-methyltransferase

NP_080786.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026510.1 → NP_080786.1 rRNA methyltransferase 2, mitochondrial

See identical proteins and their annotated locations for NP_080786.1

Status: PROVISIONAL

Source sequence(s)

AK009656

Consensus CDS

CCDS39355.1

UniProtKB/Swiss-Prot

Q9CPY0

Related

ENSMUSP00000031536.8, ENSMUST00000031536.8

Conserved Domains (1) summary

COG0293
Location:33 → 239

RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]