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    USP21 ubiquitin specific peptidase 21 [ Homo sapiens (human) ]

    Gene ID: 27005, updated on 10-Dec-2024

    Summary

    Official Symbol
    USP21provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 21provided by HGNC
    Primary source
    HGNC:HGNC:12620
    See related
    Ensembl:ENSG00000143258 MIM:604729; AllianceGenome:HGNC:12620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP16; USP23
    Summary
    This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 11.4), testis (RPKM 9.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See USP21 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161159500..161165723)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160296946..160303180)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161129290..161135513)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA ACA64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161120104-161120964 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:161123368-161124567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1470 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161137271-161137934 Neighboring gene protoporphyrinogen oxidase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1471 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161146985-161147484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161148623-161149124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1983 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161162728-161163541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161166678-161167583 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3394

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables cysteine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables deNEDDylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21
    Names
    NEDD8-specific protease
    deubiquitinating enzyme 21
    ubiquitin specific protease 21
    ubiquitin thioesterase 21
    ubiquitin thiolesterase 21
    ubiquitin-specific processing protease 21
    ubiquitin-specific protease 16
    NP_001014443.1
    NP_001306776.1
    NP_001306777.1
    NP_036607.3
    XP_016856525.1
    XP_016856526.1
    XP_016856527.1
    XP_016856528.1
    XP_047273935.1
    XP_047273936.1
    XP_047273937.1
    XP_047273938.1
    XP_047273939.1
    XP_054191967.1
    XP_054191968.1
    XP_054191969.1
    XP_054191970.1
    XP_054191971.1
    XP_054191972.1
    XP_054191973.1
    XP_054191974.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014443.3NP_001014443.1  ubiquitin carboxyl-terminal hydrolase 21 isoform c

      See identical proteins and their annotated locations for NP_001014443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1 and 3 both encode the same isoform (c).
      Source sequence(s)
      AF177758, AI038040, BC090946, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q59H60, Q5BKT5, Q5VTW9, Q5VTX0, Q9BTV1, Q9HBS2, Q9NYN4, Q9UK80
      Related
      ENSP00000356981.3, ENST00000368002.8
      Conserved Domains (2) summary
      cd02674
      Location:213556
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:212555
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_001319847.2NP_001306776.1  ubiquitin carboxyl-terminal hydrolase 21 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (a).
      Source sequence(s)
      AI038040, AK310326, DA000829
      Conserved Domains (2) summary
      cd02674
      Location:242585
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:241584
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. NM_001319848.2NP_001306777.1  ubiquitin carboxyl-terminal hydrolase 21 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction in the 3' end compared to variant 4. The resulting isoform (b) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AF217979, AF233442, AI038040, DA000829
      Consensus CDS
      CCDS81392.1
      UniProtKB/Swiss-Prot
      Q9UK80
      Related
      ENSP00000356980.1, ENST00000368001.1
      Conserved Domains (3) summary
      cd02674
      Location:213542
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:212346
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:212541
      UCH; Ubiquitin carboxyl-terminal hydrolase
    4. NM_012475.5NP_036607.3  ubiquitin carboxyl-terminal hydrolase 21 isoform c

      See identical proteins and their annotated locations for NP_036607.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1 and 3 both encode the same isoform (c).
      Source sequence(s)
      AF177758, AI038040, BI755746
      Consensus CDS
      CCDS30920.1
      UniProtKB/Swiss-Prot
      Q59H60, Q5BKT5, Q5VTW9, Q5VTX0, Q9BTV1, Q9HBS2, Q9NYN4, Q9UK80
      Related
      ENSP00000289865.8, ENST00000289865.12
      Conserved Domains (2) summary
      cd02674
      Location:213556
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:212555
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161159500..161165723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417980.1XP_047273936.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    2. XM_047417981.1XP_047273937.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X2

      UniProtKB/TrEMBL
      A0A8Q3SIU3
    3. XM_017001038.3XP_016856527.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    4. XM_017001037.3XP_016856526.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    5. XM_017001039.3XP_016856528.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    6. XM_047417982.1XP_047273938.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X3

    7. XM_017001036.2XP_016856525.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X5

    8. XM_047417979.1XP_047273935.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    9. XM_047417983.1XP_047273939.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160296946..160303180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335996.1XP_054191971.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X2

      UniProtKB/TrEMBL
      A0A8Q3SIU3
    2. XM_054335997.1XP_054191972.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X3

    3. XM_054335995.1XP_054191970.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    4. XM_054335994.1XP_054191969.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    5. XM_054335993.1XP_054191968.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    6. XM_054335999.1XP_054191974.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X5

    7. XM_054335992.1XP_054191967.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

    8. XM_054335998.1XP_054191973.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016572.3: Suppressed sequence

      Description
      NM_016572.3: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.