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    ADY2 Ady2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ADY2
    Official Full Name
    Ady2p
    Primary source
    SGD:S000000603
    Locus tag
    YCR010C
    See related
    AllianceGenome:SGD:S000000603; FungiDB:YCR010C; VEuPathDB:YCR010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ATO1
    Summary
    Enables acetate transmembrane transporter activity and ammonium channel activity. Involved in acetate transport; ammonium transmembrane transport; and nitrogen utilization. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ADY2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (132273..133124, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase SAT4 Neighboring gene amphiphysin-like protein RVS161 Neighboring gene putative ATP-dependent permease ADP1 Neighboring gene phosphoglycerate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporter. Váchová L, et al. Environ Microbiol, 2009 Jul. PMID 19302539
    2. New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity. Rendulić T, et al. Comput Struct Biotechnol J, 2021. PMID 34471488, Free PMC Article
    3. Identification and application of keto acids transporters in Yarrowia lipolytica. Guo H, et al. Sci Rep, 2015 Jan 30. PMID 25633653, Free PMC Article
    4. Deletion of JEN1 and ADY2 reduces lactic acid yield from an engineered Saccharomyces cerevisiae, in xylose medium, expressing a heterologous lactate dehydrogenase. Turner TL, et al. FEMS Yeast Res, 2019 Sep 1. PMID 31505595
    5. Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica. Gentsch M, et al. FEMS Yeast Res, 2007 May. PMID 17233767

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. deletion of SNF1 abolishes the increase of histone H3 acetylation at the promoter of the glucose-repressed ADY2 gene, and as a consequence profoundly affects the chromatin structural alterations accompanying transcriptional activation
      Title: Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter.
    2. there is an interaction between molecules of the same Ato protein, namely Ato1p-Ato1p and Ato3p-Ato3p, but not Ato2p-Ato2p
      Title: Ato protein interactions in yeast plasma membrane revealed by fluorescence lifetime imaging (FLIM).
    3. study demonstrated that monocarboxylate transporters Jen1 and Ady2 are modulators of lactic acid production
      Title: Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2.
    4. The authors show that neighbouring microcolonies coordinate production of Ato1p-green fluorescent protein.
      Title: Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporter.
    5. These data suggest that besides the ammonia induction of Ato protein synthesis, pH may rapidly regulate Ato1p function.
      Title: Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ammonium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ady2p
    NP_009936.1
    • Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      132273..133124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178723.1 → NP_009936.1  TPA: Ady2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR19, P25613
      UniProtKB/TrEMBL
      A6ZTJ1, B3LU81, C7GQM2, C8Z497, G2WA27, N1P694
      Conserved Domains (1) summary
      pfam01184
      Location:71 → 276
      Grp1_Fun34_YaaH; GPR1/FUN34/yaaH family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25613.1

    Gene LinkOut

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