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    FAM153A family with sequence similarity 153 member A [ Homo sapiens (human) ]

    Gene ID: 285596, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FAM153Aprovided by HGNC
    Official Full Name
    family with sequence similarity 153 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:29940
    See related
    Ensembl:ENSG00000170074 AllianceGenome:HGNC:29940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NY-REN-7
    Expression
    Biased expression in testis (RPKM 10.8), spleen (RPKM 4.8) and 7 other tissues See more
    Orthologs
    all
    NEW
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    Try the new Transcript table

    Genomic context

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    See FAM153A in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177694247..177783425, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178237719..178327515, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177138050..177210426, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177033623-177034226 Neighboring gene beta-1,4-galactosyltransferase 7 Neighboring gene SIMC1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16706 Neighboring gene uncharacterized LOC107986489 Neighboring gene MPRA-validated peak5597 silencer Neighboring gene uncharacterized LOC100419951 Neighboring gene FAM83G pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Scanlan MJ, et al. Int J Cancer, 1999 Nov 12. PMID 10508479
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Oct 30. PMID 9872452
    3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ75901, KIAA0752

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM153A
    Names
    NY REN 7 antigen
    renal carcinoma antigen NY-REN-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394339.1 → NP_001381268.1  protein FAM153A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140125
      Consensus CDS
      CCDS93833.1
      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Related
      ENSP00000481950.1, ENST00000614127.5

    2. NM_001413826.1 → NP_001400755.1  protein FAM153A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140125
      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3
      Related
      ENSP00000513119.1, ENST00000697116.2

    3. NM_173663.5 → NP_775934.3  protein FAM153A isoform 1

      See identical proteins and their annotated locations for NP_775934.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the protein.
      Source sequence(s)
      AC140125, AF155097, DA217331
      Consensus CDS
      CCDS34305.1
      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3
      UniProtKB/TrEMBL
      A0A8V8TKQ6
      Related
      ENSP00000513120.1, ENST00000697117.1
      Conserved Domains (1) summary
      pfam15722
      Location:178 → 310
      FAM153; FAM153 family

    RNA

    1. NR_146226.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC138819, AC140125, DB306163
      Related
      ENST00000503845.6

    2. NR_146227.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC138819, AC140125, DB306163

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      177694247..177783425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009359.2 → XP_016864848.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    2. XM_017009358.2 → XP_016864847.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    3. XM_017009364.2 → XP_016864853.1  protein FAM153A isoform X5

      UniProtKB/TrEMBL
      A0A8V8TKQ6

    4. XM_017009369.2 → XP_016864858.1  protein FAM153A isoform X7

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3
      UniProtKB/TrEMBL
      A0A8V8TKQ6
      Related
      ENSP00000513116.1, ENST00000697112.1
      Conserved Domains (1) summary
      pfam15722
      Location:178 → 310
      FAM153; FAM153 family

    5. XM_017009365.2 → XP_016864854.1  protein FAM153A isoform X6

      UniProtKB/TrEMBL
      A0A8V8TKQ6

    6. XM_017009363.2 → XP_016864852.1  protein FAM153A isoform X5

      UniProtKB/TrEMBL
      A0A8V8TKQ6

    7. XM_011534521.4 → XP_011532823.1  protein FAM153A isoform X7

      See identical proteins and their annotated locations for XP_011532823.1

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3
      UniProtKB/TrEMBL
      A0A8V8TKQ6
      Conserved Domains (1) summary
      pfam15722
      Location:178 → 310
      FAM153; FAM153 family

    8. XM_006714849.4 → XP_006714912.1  protein FAM153A isoform X7

      See identical proteins and their annotated locations for XP_006714912.1

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3
      UniProtKB/TrEMBL
      A0A8V8TKQ6
      Related
      ENSP00000513114.1, ENST00000697109.1
      Conserved Domains (1) summary
      pfam15722
      Location:178 → 310
      FAM153; FAM153 family

    9. XM_017009362.2 → XP_016864851.1  protein FAM153A isoform X4

      UniProtKB/TrEMBL
      A0A8V8TKQ6, A0A8V8TM68
      Related
      ENSP00000513109.1, ENST00000697103.1
      Conserved Domains (1) summary
      pfam15722
      Location:207 → 339
      FAM153; FAM153 family

    10. XM_047417108.1 → XP_047273064.1  protein FAM153A isoform X9

    11. XM_011534528.3 → XP_011532830.1  protein FAM153A isoform X8

      Conserved Domains (1) summary
      pfam15722
      Location:123 → 255
      FAM153; FAM153 family

    12. XM_011534520.3 → XP_011532822.1  protein FAM153A isoform X2

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A8V8TKN8
      Related
      ENSP00000513110.1, ENST00000697104.1
      Conserved Domains (1) summary
      pfam15722
      Location:253 → 385
      FAM153; FAM153 family

    13. XM_047417106.1 → XP_047273062.1  protein FAM153A isoform X3

    14. XM_017009356.2 → XP_016864845.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    15. XM_017009354.2 → XP_016864843.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    16. XM_005265889.4 → XP_005265946.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    17. XM_017009360.2 → XP_016864849.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    18. XM_017009361.2 → XP_016864850.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    19. XM_017009357.2 → XP_016864846.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    20. XM_017009352.2 → XP_016864841.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    21. XM_017009355.2 → XP_016864844.1  protein FAM153A isoform X1

      UniProtKB/Swiss-Prot
      A8MTI1, P0C7A2
      UniProtKB/TrEMBL
      A0A087WYN1
      Conserved Domains (1) summary
      pfam15722
      Location:255 → 387
      FAM153; FAM153 family

    22. XM_047417107.1 → XP_047273063.1  protein FAM153A isoform X7

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      178237719..178327515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352402.1 → XP_054208377.1  protein FAM153A isoform X10

    2. XM_054352401.1 → XP_054208376.1  protein FAM153A isoform X10

    3. XM_054352410.1 → XP_054208385.1  protein FAM153A isoform X7

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3

    4. XM_054352408.1 → XP_054208383.1  protein FAM153A isoform X5

    5. XM_054352412.1 → XP_054208387.1  protein FAM153A isoform X7

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3

    6. XM_054352413.1 → XP_054208388.1  protein FAM153A isoform X7

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3

    7. XM_054352409.1 → XP_054208384.1  protein FAM153A isoform X6

    8. XM_054352407.1 → XP_054208382.1  protein FAM153A isoform X5

    9. XM_054352414.1 → XP_054208389.1  protein FAM153A isoform X7

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3

    10. XM_054352406.1 → XP_054208381.1  protein FAM153A isoform X13

    11. XM_054352411.1 → XP_054208386.1  protein FAM153A isoform X7

      UniProtKB/Swiss-Prot
      A8K0F3, O94852, Q9UHL3

    12. XM_054352416.1 → XP_054208391.1  protein FAM153A isoform X15

    13. XM_054352415.1 → XP_054208390.1  protein FAM153A isoform X14

    14. XM_054352404.1 → XP_054208379.1  protein FAM153A isoform X11

    15. XM_054352405.1 → XP_054208380.1  protein FAM153A isoform X12

    16. XM_054352400.1 → XP_054208375.1  protein FAM153A isoform X10

    17. XM_054352399.1 → XP_054208374.1  protein FAM153A isoform X10

    18. XM_054352396.1 → XP_054208371.1  protein FAM153A isoform X10

    19. XM_054352403.1 → XP_054208378.1  protein FAM153A isoform X10

    20. XM_054352398.1 → XP_054208373.1  protein FAM153A isoform X10

    21. XM_054352397.1 → XP_054208372.1  protein FAM153A isoform X10

    22. XM_054352395.1 → XP_054208370.1  protein FAM153A isoform X10

    23. XM_054352394.1 → XP_054208369.1  protein FAM153A isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UHL3.2 GenPept UniProtKB/Swiss-Prot:Q9UHL3

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