Fis1 fission, mitochondrial 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fis1provided by RGD
Official Full Name: fission, mitochondrial 1provided by RGD
Primary source: RGD:1306668
See related: EnsemblRapid:ENSRNOG00000001420 AllianceGenome:RGD:1306668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ttc11
Summary: Predicted to enable identical protein binding activity; lipid binding activity; and molecular adaptor activity. Involved in several processes, including cellular response to peptide; mitochondrial fragmentation involved in apoptotic process; and positive regulation of mitochondrial fission. Located in mitochondrial outer membrane and peroxisomal membrane. Biomarker of dental fluorosis; kidney failure (multiple); myocardial infarction; rhinitis; and steatotic liver disease. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 354.2), Heart (RPKM 334.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (25345239..25360135, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19708560..19723392, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22750485..22765324, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Right ventricular ischemia occurs in pulmonary arterial hypertension and causes Drp1-Fis1-mediated fission leading to diastolic dysfunction.
Title: Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
In the renal tissues of rats with chronic fluorosis, expression of both Mfn1 protein and mRNA was clearly reduced, whereas that of Fis1 was elevated.
Title: The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress.
Excessive intake of fluoride results in an altered mitochondrial distribution in axon and soma in cortical neurons, increased expression of Fis1 gene and enhanced mitochondrial fission.
Title: [Alteration of mitochondrial distribution and gene expression of fission 1 protein in cortical neurons of rats with chronic fluorosis].
Fis1 and Mfn1 activities influence mitochondrial signal generation thereby insulin exocytosis.
Title: Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.
These experiments revealed that the N-terminal and C-terminal segments are both essential for oligomeric rFis1 interaction, and the middle TPR-like domains regulate proper oligomer assembly.
Title: Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142325 (e-PCR)
- UniSTS:231572

RH142876 (e-PCR)
- UniSTS:232123

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fragmentation involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	IEA Inferred from Electronic Annotation more info
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to flavonoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fluoride	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypobaric hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial fission 1 protein

Names: TPR repeat protein 11; fis1 homolog; fission 1 (mitochondrial outer membrane) homolog; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105919.2 → NP_001099389.1 mitochondrial fission 1 protein isoform 1

See identical proteins and their annotated locations for NP_001099389.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8L2URI1

Conserved Domains (1) summary

cd12212
Location:4 → 116

Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
NM_001401051.1 → NP_001387980.1 mitochondrial fission 1 protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

B2RZ80, D4A5K3, P84817

UniProtKB/TrEMBL

A0A8L2URI1, A6J062

Related

ENSRNOP00000075023.2, ENSRNOT00000083471.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

25345239..25360135 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249122.5 → XP_006249184.1 mitochondrial fission 1 protein isoform X2

See identical proteins and their annotated locations for XP_006249184.1

UniProtKB/Swiss-Prot

P84817

Conserved Domains (2) summary

cd12212
Location:4 → 113

Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

cl14647
Location:118 → 154

GH43_62_32_68; Glycosyl hydrolase families: GH43, GH62, GH32, GH68
XM_006249121.5 → XP_006249183.1 mitochondrial fission 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I6A509

Related

ENSRNOP00000061895.3, ENSRNOT00000063901.5

Conserved Domains (2) summary

cd12212
Location:9 → 120

Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

cl14647
Location:125 → 161

GH43_62_32_68; Glycosyl hydrolase families: GH43, GH62, GH32, GH68