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    Plekhg3 pleckstrin homology and RhoGEF domain containing G3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekhg3provided by RGD
    Official Full Name
    pleckstrin homology and RhoGEF domain containing G3provided by RGD
    Primary source
    RGD:1308089
    See related
    EnsemblRapid:ENSRNOG00000006570 AllianceGenome:RGD:1308089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308089
    Summary
    Predicted to enable actin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in regulation of cell migration and regulation of establishment of cell polarity. Orthologous to human PLEKHG3 (pleckstrin homology and RhoGEF domain containing G3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.0), Brain (RPKM 45.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhg3 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (100998965..101042120)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95265756..95308952)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99612993..99655753)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556012 Neighboring gene ribosomal protein S17 like 1 Neighboring gene spectrin, beta, erythrocytic Neighboring gene uncharacterized LOC134479402

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology and RhoGEF domain containing G3; pleckstrin homology domain-containing family G member 3
    Names
    pleckstrin homology domain containing, family G (with RhoGef domain) member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431908.1 → NP_001418837.1  pleckstrin homology and RhoGEF domain containing G3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A394, A0A8I6ATN8

    2. NM_001431909.1 → NP_001418838.1  pleckstrin homology and RhoGEF domain containing G3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A394

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      100998965..101042120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594466.3 → XP_017449955.1  pleckstrin homology domain-containing family G member 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A394
      Conserved Domains (2) summary
      cd13243
      Location:253 → 396
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:97 → 270
      RhoGEF; RhoGEF domain

    2. XM_063262762.1 → XP_063118832.1  pleckstrin homology domain-containing family G member 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A394
      Related
      ENSRNOP00000097983.2, ENSRNOT00000105013.2

    3. XM_063262765.1 → XP_063118835.1  pleckstrin homology domain-containing family G member 3 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A394

    4. XM_063262763.1 → XP_063118833.1  pleckstrin homology domain-containing family G member 3 isoform X9

      Related
      ENSRNOP00000108696.1, ENSRNOT00000156659.1

    5. XM_063262766.1 → XP_063118836.1  pleckstrin homology domain-containing family G member 3 isoform X12

    6. XM_017594469.3 → XP_017449958.2  pleckstrin homology domain-containing family G member 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A394
      Conserved Domains (2) summary
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 291
      RhoGEF; RhoGEF domain

    7. XM_017594465.3 → XP_017449954.1  pleckstrin homology domain-containing family G member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A394

    8. XM_017594464.3 → XP_017449953.2  pleckstrin homology domain-containing family G member 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A394
      Conserved Domains (2) summary
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 291
      RhoGEF; RhoGEF domain

    9. XM_017594471.3 → XP_017449960.2  pleckstrin homology domain-containing family G member 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A394
      Conserved Domains (2) summary
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 291
      RhoGEF; RhoGEF domain

    10. XM_063262761.1 → XP_063118831.1  pleckstrin homology domain-containing family G member 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A394

    11. XM_039113273.2 → XP_038969201.1  pleckstrin homology domain-containing family G member 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A394
      Conserved Domains (2) summary
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 291
      RhoGEF; RhoGEF domain

    12. XM_063262764.1 → XP_063118834.1  pleckstrin homology domain-containing family G member 3 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A394

    13. XM_017594472.3 → XP_017449961.2  pleckstrin homology domain-containing family G member 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A394, D3ZA21
      Related
      ENSRNOP00000008573.6, ENSRNOT00000008573.9
      Conserved Domains (2) summary
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 291
      RhoGEF; RhoGEF domain

    14. XM_017594473.3 → XP_017449962.1  pleckstrin homology domain-containing family G member 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I6A394
    Nucleotide Protein Strain
    Heading Accession and Version

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