Shc4 SHC adaptor protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shc4provided by RGD
Official Full Name: SHC adaptor protein 4provided by RGD
Primary source: RGD:1583644
See related: EnsemblRapid:ENSRNOG00000037134 AllianceGenome:RGD:1583644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309182
Summary: Predicted to enable protein domain specific binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be active in plasma membrane. Orthologous to human SHC4 (SHC adaptor protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 40.8), Brain (RPKM 11.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (133334026..133428404, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (112880598..112974216, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (117897738..117990289, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ShcD shows relatively widespread distribution in the adult brain and spinal cord, with prominent levels of staining throughout the olfactory bulb, as well as in sub-structures of the cerebellum and hippocampus, including the subgranular zone. Co-localization studies confirm the expression of ShcD in mature neurons and progenitor cells. ShcD immunoreactivity is primarily localized to axons and somata.
Title: Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system.

Submit: New GeneRIF Correction

General gene information

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Markers

BI281881 (e-PCR)
- UniSTS:249603

RH129470 (e-PCR)
- UniSTS:212776

RH139161 (e-PCR)
- UniSTS:221247

BE107507 (e-PCR)
- UniSTS:246904

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SHC-transforming protein 4

Names: SHC (Src homology 2 domain containing) family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191065.2 → NP_001177994.1 SHC-transforming protein 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

D4A3K2

Related

ENSRNOP00000011084.3, ENSRNOT00000011084.5

Conserved Domains (2) summary

cd09925
Location:510 → 609

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:181 → 347

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

133334026..133428404 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284538.1 → XP_063140608.1 SHC-transforming protein 4 isoform X1

Related

ENSRNOP00000110963.1, ENSRNOT00000145550.1
XM_039105836.2 → XP_038961764.1 SHC-transforming protein 4 isoform X2

Conserved Domains (2) summary

cd09925
Location:224 → 323

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cl17171
Location:1 → 61

PH-like; Pleckstrin homology-like domain