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    Pacs2 phosphofurin acidic cluster sorting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pacs2provided by RGD
    Official Full Name
    phosphofurin acidic cluster sorting protein 2provided by RGD
    Primary source
    RGD:1597262
    See related
    EnsemblRapid:ENSRNOG00000014744 AllianceGenome:RGD:1597262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and protein localization to plasma membrane. Predicted to act upstream of or within protein localization to phagophore assembly site. Predicted to be located in endoplasmic reticulum and mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 66. Orthologous to human PACS2 (phosphofurin acidic cluster sorting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 163.7), Thymus (RPKM 114.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pacs2 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137918040..137977767)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (132096992..132156702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137824136..137889144)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 14 Neighboring gene BRF1 general transcription factor IIIB subunit Neighboring gene BTB domain containing 6 Neighboring gene uncharacterized LOC134479482 Neighboring gene uncharacterized LOC134479483 Neighboring gene U4 spliceosomal RNA Neighboring gene testis expressed 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling. Shen Z, et al. Int Immunopharmacol, 2024 Nov 15. PMID 39173402
    2. MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure. Zhou F, et al. Eur Rev Med Pharmacol Sci, 2019 Jun. PMID 31210325
    3. miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2. Wang J, et al. RNA Biol, 2014. PMID 24646523, Free PMC Article
    4. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. Simmen T, et al. EMBO J, 2005 Feb 23. PMID 15692567, Free PMC Article
    5. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. Köttgen M, et al. EMBO J, 2005 Feb 23. PMID 15692563, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling.
      Title: Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling.
    2. MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure.
      Title: MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure.
    3. miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2.
      Title: miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphofurin acidic cluster sorting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427329.1 → NP_001414258.1  phosphofurin acidic cluster sorting protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A754
      Related
      ENSRNOP00000088053.1, ENSRNOT00000111416.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137918040..137977767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240668.5 → XP_006240730.1  phosphofurin acidic cluster sorting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006240730.1

      UniProtKB/TrEMBL
      A0A8I6A754, D3ZJG4
      Related
      ENSRNOP00000053720.4, ENSRNOT00000056880.7
      Conserved Domains (1) summary
      pfam10254
      Location:473 → 898
      Pacs-1; PACS-1 cytosolic sorting protein

    2. XM_063262529.1 → XP_063118599.1  phosphofurin acidic cluster sorting protein 2 isoform X8

    3. XM_017594524.3 → XP_017450013.1  phosphofurin acidic cluster sorting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A754

    4. XM_039113422.2 → XP_038969350.1  phosphofurin acidic cluster sorting protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A754
      Conserved Domains (1) summary
      pfam10254
      Location:448 → 873
      Pacs-1; PACS-1 cytosolic sorting protein

    5. XM_017594525.3 → XP_017450014.1  phosphofurin acidic cluster sorting protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A754

    6. XM_063262528.1 → XP_063118598.1  phosphofurin acidic cluster sorting protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A754

    7. XM_017594526.2 → XP_017450015.1  phosphofurin acidic cluster sorting protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A831

    8. XM_039113423.2 → XP_038969351.1  phosphofurin acidic cluster sorting protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A831
      Conserved Domains (1) summary
      pfam10254
      Location:406 → 831
      Pacs-1; PACS-1 cytosolic sorting protein

    RNA

    1. XR_005506363.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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