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    COR1 ubiquinol--cytochrome-c reductase subunit COR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COR1
    Official Full Name
    ubiquinol--cytochrome-c reductase subunit COR1
    Primary source
    SGD:S000000141
    Locus tag
    YBL045C
    See related
    AllianceGenome:SGD:S000000141; FungiDB:YBL045C; VEuPathDB:YBL045C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    QCR1
    Summary
    Contributes to ubiquinol-cytochrome-c reductase activity. Involved in aerobic respiration. Located in mitochondrion. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COR1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (134143..135516, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ede1p Neighboring gene Psy4p Neighboring gene uncharacterized protein Neighboring gene Ecm13p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the mitochondrial bc1 complex. Properties of the complex in temperature-sensitive cor1 mutants. Gatti DL, et al. J Biol Chem, 1990 Dec 15. PMID 2174874
    2. Assembly of the mitochondrial membrane system. Characterization of COR1, the structural gene for the 44-kilodalton core protein of yeast coenzyme QH2-cytochrome c reductase. Tzagoloff A, et al. J Biol Chem, 1986 Dec 25. PMID 3023384
    3. Characterization of the yeast HEM2 gene and transcriptional regulation of COX5 and COR1 by heme. Myers AM, et al. J Biol Chem, 1987 Dec 15. PMID 2445751
    4. Core I protein of bovine ubiquinol-cytochrome-c reductase; an additional member of the mitochondrial-protein-processing family. Cloning of bovine core I and core II cDNAs and primary structure of the proteins. Gencic S, et al. Eur J Biochem, 1991 Jul 1. PMID 1712295
    5. Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Hill S, et al. Free Radic Biol Med, 2012 Aug 15. PMID 22705367, Free PMC Article

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquinol-cytochrome-c reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquinol--cytochrome-c reductase subunit COR1
    NP_009508.1
    • Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      134143..135516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178285.1 → NP_009508.1  TPA: ubiquinol--cytochrome-c reductase subunit COR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPV3, P07256
      UniProtKB/TrEMBL
      A6ZKQ2, C8Z3Q3, G2W8W2, N1P7D3
      Conserved Domains (1) summary
      COG0612
      Location:25 → 445
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07256.1

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