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    Ankrd24 ankyrin repeat domain 24 [ Mus musculus (house mouse) ]

    Gene ID: 70615, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ankrd24provided by MGI
    Official Full Name
    ankyrin repeat domain 24provided by MGI
    Primary source
    MGI:MGI:1890394
    See related
    Ensembl:ENSMUSG00000054708 AllianceGenome:MGI:1890394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D10Bur2e; 4631433D01Rik; 5730519E19Rik
    Summary
    Predicted to enable actin binding activity. Involved in auditory receptor cell stereocilium organization and sensory perception of sound. Located in plasma membrane and stereocilium. Is expressed in cochlea; olfactory epithelium; pituitary gland; vagus ganglion; and vestibulo-cochlear ganglion. Orthologous to human ANKRD24 (ankyrin repeat domain 24). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 10.1), CNS E18 (RPKM 9.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd24 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81464352..81483446)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81627821..81647612)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E464 Neighboring gene zinc finger protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_27345 Neighboring gene STARR-positive B cell enhancer ABC_E6888 Neighboring gene sirtuin 6 Neighboring gene STARR-positive B cell enhancer ABC_E9797 Neighboring gene STARR-positive B cell enhancer ABC_E6889 Neighboring gene STARR-seq mESC enhancer starr_27348 Neighboring gene predicted gene 10778 Neighboring gene predicted gene, 51792 Neighboring gene predicted gene 8112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points. Krey JF, et al. J Cell Biol, 2022 Apr 4. PMID 35175278, Free PMC Article
    2. Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Puttagunta R, et al. Genome Res, 2000 Sep. PMID 10984455, Free PMC Article
    3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points.
      Title: ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in auditory receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374016.1 → NP_001360945.1  ankyrin repeat domain-containing protein 24 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153919
      Conserved Domains (6) summary
      PTZ00322
      Location:190 → 311
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:56 → 243
      PHA02875; ankyrin repeat protein; Provisional
      COG1196
      Location:319 → 538
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:325 → 985
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:116 → 146
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:120 → 212
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_027480.3 → NP_081756.4  ankyrin repeat domain-containing protein 24 isoform 2

      See identical proteins and their annotated locations for NP_081756.4

      Status: VALIDATED

      Source sequence(s)
      AC153919, AK043638, BC017633, CB524981, CJ177454, CJ183294, CJ243196
      Consensus CDS
      CCDS36001.1
      UniProtKB/Swiss-Prot
      E9QJV7, Q80VM7
      Related
      ENSMUSP00000112932.2, ENSMUST00000119336.8
      Conserved Domains (6) summary
      PTZ00322
      Location:160 → 281
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:26 → 213
      PHA02875; ankyrin repeat protein; Provisional
      COG1196
      Location:289 → 508
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:295 → 955
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:86 → 116
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81464352..81483446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514093.5 → XP_006514156.1  ankyrin repeat domain-containing protein 24 isoform X3

      See identical proteins and their annotated locations for XP_006514156.1

      Conserved Domains (5) summary
      PTZ00322
      Location:189 → 310
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:55 → 242
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:324 → 1024
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:115 → 145
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:119 → 211
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_030245274.2 → XP_030101134.1  ankyrin repeat domain-containing protein 24 isoform X14

      UniProtKB/TrEMBL
      Q8VD21
      Conserved Domains (1) summary
      TIGR02168
      Location:384 → 566
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006514096.5 → XP_006514159.1  ankyrin repeat domain-containing protein 24 isoform X5

      Conserved Domains (5) summary
      PTZ00322
      Location:160 → 281
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:26 → 213
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:295 → 995
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:86 → 116
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006514098.5 → XP_006514161.1  ankyrin repeat domain-containing protein 24 isoform X7

      See identical proteins and their annotated locations for XP_006514161.1

      UniProtKB/Swiss-Prot
      E9QJV7, Q80VM7
      Conserved Domains (6) summary
      PTZ00322
      Location:160 → 281
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:26 → 213
      PHA02875; ankyrin repeat protein; Provisional
      COG1196
      Location:289 → 508
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:295 → 955
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:86 → 116
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_006514102.5 → XP_006514165.1  ankyrin repeat domain-containing protein 24 isoform X10

      See identical proteins and their annotated locations for XP_006514165.1

      Conserved Domains (4) summary
      PTZ00322
      Location:65 → 186
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:200 → 900
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:23 → 54
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:28 → 120
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_006514094.5 → XP_006514157.1  ankyrin repeat domain-containing protein 24 isoform X3

      See identical proteins and their annotated locations for XP_006514157.1

      Conserved Domains (5) summary
      PTZ00322
      Location:189 → 310
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:55 → 242
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:324 → 1024
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:115 → 145
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:119 → 211
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_036156008.1 → XP_036011901.1  ankyrin repeat domain-containing protein 24 isoform X8

      Conserved Domains (4) summary
      TIGR02168
      Location:234 → 934
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:25 → 55
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 45
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:29 → 121
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_036156013.1 → XP_036011906.1  ankyrin repeat domain-containing protein 24 isoform X12

      Conserved Domains (4) summary
      PTZ00322
      Location:16 → 137
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:151 → 851
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:7 → 38
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 71
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_006514103.5 → XP_006514166.1  ankyrin repeat domain-containing protein 24 isoform X10

      See identical proteins and their annotated locations for XP_006514166.1

      Conserved Domains (4) summary
      PTZ00322
      Location:65 → 186
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:200 → 900
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:23 → 54
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:28 → 120
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_006514091.5 → XP_006514154.1  ankyrin repeat domain-containing protein 24 isoform X1

      Conserved Domains (5) summary
      PTZ00322
      Location:207 → 328
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:73 → 260
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:342 → 1042
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:133 → 163
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_006514097.5 → XP_006514160.1  ankyrin repeat domain-containing protein 24 isoform X6

      Conserved Domains (6) summary
      PTZ00322
      Location:207 → 328
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:73 → 260
      PHA02875; ankyrin repeat protein; Provisional
      COG1196
      Location:336 → 555
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:342 → 1002
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:133 → 163
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_006514092.5 → XP_006514155.1  ankyrin repeat domain-containing protein 24 isoform X2

      Conserved Domains (5) summary
      PTZ00322
      Location:190 → 311
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:56 → 243
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:325 → 1025
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:116 → 146
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:120 → 212
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_006514095.5 → XP_006514158.1  ankyrin repeat domain-containing protein 24 isoform X4

      Conserved Domains (5) summary
      PTZ00322
      Location:161 → 282
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:27 → 214
      PHA02875; ankyrin repeat protein; Provisional
      TIGR02168
      Location:296 → 996
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:87 → 117
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:91 → 183
      Ank_2; Ankyrin repeats (3 copies)

    14. XM_006514099.5 → XP_006514162.1  ankyrin repeat domain-containing protein 24 isoform X8

      See identical proteins and their annotated locations for XP_006514162.1

      Conserved Domains (4) summary
      TIGR02168
      Location:234 → 934
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:25 → 55
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 45
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:29 → 121
      Ank_2; Ankyrin repeats (3 copies)

    15. XM_006514101.5 → XP_006514164.1  ankyrin repeat domain-containing protein 24 isoform X9

      Conserved Domains (4) summary
      PTZ00322
      Location:66 → 187
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:201 → 901
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:24 → 55
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 121
      Ank_2; Ankyrin repeats (3 copies)

    16. XM_036156009.1 → XP_036011902.1  ankyrin repeat domain-containing protein 24 isoform X11

      Conserved Domains (4) summary
      PTZ00322
      Location:56 → 177
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:191 → 891
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:14 → 45
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:19 → 111
      Ank_2; Ankyrin repeats (3 copies)

    17. XM_036156010.1 → XP_036011903.1  ankyrin repeat domain-containing protein 24 isoform X12

      Conserved Domains (4) summary
      PTZ00322
      Location:16 → 137
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:151 → 851
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:7 → 38
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 71
      Ank_2; Ankyrin repeats (3 copies)

    18. XM_036156011.1 → XP_036011904.1  ankyrin repeat domain-containing protein 24 isoform X12

      Conserved Domains (4) summary
      PTZ00322
      Location:16 → 137
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:151 → 851
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:7 → 38
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 71
      Ank_2; Ankyrin repeats (3 copies)

    19. XM_036156012.1 → XP_036011905.1  ankyrin repeat domain-containing protein 24 isoform X12

      Conserved Domains (4) summary
      PTZ00322
      Location:16 → 137
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:151 → 851
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:7 → 38
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 71
      Ank_2; Ankyrin repeats (3 copies)

    20. XM_006514104.5 → XP_006514167.1  ankyrin repeat domain-containing protein 24 isoform X12

      Conserved Domains (4) summary
      PTZ00322
      Location:16 → 137
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:151 → 851
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:7 → 38
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 71
      Ank_2; Ankyrin repeats (3 copies)

    21. XM_030245275.1 → XP_030101135.1  ankyrin repeat domain-containing protein 24 isoform X14

      UniProtKB/TrEMBL
      Q8VD21
      Conserved Domains (1) summary
      TIGR02168
      Location:384 → 566
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    22. XM_011243569.1 → XP_011241871.1  ankyrin repeat domain-containing protein 24 isoform X11

      Conserved Domains (4) summary
      PTZ00322
      Location:56 → 177
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      TIGR02168
      Location:191 → 891
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:14 → 45
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:19 → 111
      Ank_2; Ankyrin repeats (3 copies)

    23. XM_017314088.1 → XP_017169577.1  ankyrin repeat domain-containing protein 24 isoform X13

      UniProtKB/TrEMBL
      Q8VD21
      Conserved Domains (2) summary
      TIGR02168
      Location:485 → 667
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:23 → 174
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    24. XM_030245273.1 → XP_030101133.1  ankyrin repeat domain-containing protein 24 isoform X13

      UniProtKB/TrEMBL
      Q8VD21
      Conserved Domains (2) summary
      TIGR02168
      Location:485 → 667
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:23 → 174
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VM7.4 GenPept UniProtKB/Swiss-Prot:Q80VM7

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