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    Cib1 calcium and integrin binding 1 [ Mus musculus (house mouse) ]

    Gene ID: 23991, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cib1provided by MGI
    Official Full Name
    calcium and integrin binding 1provided by MGI
    Primary source
    MGI:MGI:1344418
    See related
    Ensembl:ENSMUSG00000030538 AllianceGenome:MGI:1344418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kip; Cibkip; Prkdcip
    Summary
    Enables protein-membrane adaptor activity and transmembrane transporter binding activity. Involved in several processes, including negative regulation of megakaryocyte differentiation; regulation of intracellular signal transduction; and regulation of protein phosphorylation. Located in cytoplasm and sarcolemma. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and integrin binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 235.6), large intestine adult (RPKM 223.6) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Cib1 in Genome Data Viewer
    Location:
    7 D2; 7 45.55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79876904..79882367, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80227156..80232805, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45202 Neighboring gene STARR-positive B cell enhancer ABC_E8182 Neighboring gene STARR-seq mESC enhancer starr_19316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87337544-87337745 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B Neighboring gene STARR-seq mESC enhancer starr_19318 Neighboring gene STARR-seq mESC enhancer starr_19319 Neighboring gene STARR-seq mESC enhancer starr_19320 Neighboring gene STARR-seq mESC enhancer starr_19323 Neighboring gene STARR-positive B cell enhancer ABC_E10446 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4940 Neighboring gene tubulin tyrosine ligase-like family, member 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables calcium-dependent protein kinase inhibitor activity  
    enables calcium-dependent protein kinase inhibitor activity  
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein serine/threonine kinase inhibitor activity  
    enables protein-membrane adaptor activity  
    enables protein-membrane adaptor activity PubMed 
    enables protein-membrane adaptor activity  
    enables small GTPase binding  
    enables small GTPase binding  
    enables transmembrane transporter binding PubMed 
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response PubMed 
    involved_in angiogenesis  
    involved_in apoptotic process  
    involved_in apoptotic process PubMed 
    involved_in cell adhesion  
    involved_in cell division  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in cytoplasmic microtubule organization  
    involved_in cytoplasmic microtubule organization  
    involved_in endomitotic cell cycle  
    involved_in endomitotic cell cycle  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of megakaryocyte differentiation PubMed 
    involved_in negative regulation of microtubule depolymerization  
    involved_in negative regulation of microtubule depolymerization  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in negative regulation of protein phosphorylation PubMed 
    involved_in platelet formation PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of calcineurin-NFAT signaling cascade PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of catalytic activity PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell-matrix adhesion PubMed 
    involved_in positive regulation of male germ cell proliferation PubMed 
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane PubMed 
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity PubMed 
    involved_in positive regulation of protein targeting to membrane  
    involved_in positive regulation of protein targeting to membrane  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in regulation of cell division  
    involved_in regulation of cell division  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cell population proliferation  
    involved_in response to ischemia PubMed 
    involved_in spermatid development PubMed 
    involved_in thrombopoietin-mediated signaling pathway PubMed 
    Items 1 - 25 of 60
    Items 1 - 20 of 41
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    is_active_in axon  
    located_in axon  
    located_in cell periphery  
    located_in cell periphery  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in dendrite  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in filopodium tip  
    located_in filopodium tip  
    located_in growth cone  
    located_in growth cone  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in membrane PubMed 
    located_in membrane  
    located_in neuron projection  
    located_in neuron projection  
    is_active_in neuronal cell body  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in ruffle membrane  
    is_active_in sarcolemma  
    located_in sarcolemma PubMed 
    located_in sarcolemma  
    Items 1 - 20 of 41

    General protein information

    Preferred Names
    calcium and integrin-binding protein 1
    Names
    CIB
    DNA-PKcs-interacting protein
    calcium and integrin binding, protein kinase interacting protein
    calmyrin
    kinase-interacting protein
    protein kinase, DNA activated, catalytic polypeptide interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291275.2NP_001278204.1  calcium and integrin-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001278204.1

      Status: VALIDATED

      Source sequence(s)
      AC109232
      Consensus CDS
      CCDS85324.1
      UniProtKB/TrEMBL
      A0A0U1RPF3
      Related
      ENSMUSP00000145961.2, ENSMUST00000206084.2
      Conserved Domains (2) summary
      cd00051
      Location:106173
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:104172
      EF-hand_7; EF-hand domain pair
    2. NM_001291276.2NP_001278205.1  calcium and integrin-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001278205.1

      Status: VALIDATED

      Source sequence(s)
      AC109232
      Consensus CDS
      CCDS80740.1
      UniProtKB/TrEMBL
      Q8C2K4
      Related
      ENSMUSP00000071401.6, ENSMUST00000071457.12
      Conserved Domains (2) summary
      cd00051
      Location:63130
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:61129
      EF-hand_7; EF-hand domain pair
    3. NM_001421973.1NP_001408902.1  calcium and integrin-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109232
    4. NM_001421974.1NP_001408903.1  calcium and integrin-binding protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109232
    5. NM_001421975.1NP_001408904.1  calcium and integrin-binding protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109232
    6. NM_001421976.1NP_001408905.1  calcium and integrin-binding protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109232
    7. NM_001421977.1NP_001408906.1  calcium and integrin-binding protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC109232
    8. NM_001421978.1NP_001408907.1  calcium and integrin-binding protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    9. NM_001421979.1NP_001408908.1  calcium and integrin-binding protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    10. NM_001421980.1NP_001408909.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    11. NM_001421981.1NP_001408910.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    12. NM_001421982.1NP_001408911.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    13. NM_001421983.1NP_001408912.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    14. NM_001421984.1NP_001408913.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    15. NM_001421985.1NP_001408914.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
      Related
      ENSMUSP00000118926.3, ENSMUST00000123279.8
    16. NM_001421986.1NP_001408915.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    17. NM_001421987.1NP_001408916.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    18. NM_001421988.1NP_001408917.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      D3YY46
    19. NM_011870.6NP_036000.1  calcium and integrin-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_036000.1

      Status: VALIDATED

      Source sequence(s)
      AC109232
      Consensus CDS
      CCDS21392.1
      UniProtKB/Swiss-Prot
      Q3TN80, Q9Z0F4
      Related
      ENSMUSP00000070901.9, ENSMUST00000065163.15
      Conserved Domains (1) summary
      cd00051
      Location:111178
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. NR_185473.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109232
    2. NR_185474.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109232
    3. NR_185475.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109232

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79876904..79882367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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