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    AME1 Ame1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AME1
    Official Full Name
    Ame1p
    Primary source
    SGD:S000000415
    Locus tag
    YBR211C
    See related
    AllianceGenome:SGD:S000000415; FungiDB:YBR211C; VEuPathDB:YBR211C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ARP100
    Summary
    Involved in attachment of spindle microtubules to kinetochore and protein localization to kinetochore. Located in kinetochore. Part of COMA complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AME1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (646158..647132, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene Erv15p Neighboring gene Ngr1p Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
      Title: Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
    2. Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
      Title: Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
    3. Findings reveal a new role for the central kinetochore in promoting Sli15 function, and suggest functional Ame1 is required for the correction of defective attachments by promoting the localization of Sli15/INCENP at kinetochores.
      Title: The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments.
    4. Ame1 and Okp1 are required for a sustained checkpoint arrest in the presence of mis-segregated chromosomes
      Title: Spindle checkpoint maintenance requires Ame1 and Okp1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in attachment of spindle microtubules to kinetochore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COMA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body HDA PubMed 

    General protein information

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    Preferred Names
    Ame1p
    NP_009770.3
    • Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      646158..647132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178559.3 → NP_009770.3  TPA: Ame1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009770.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQK7, P38313
      UniProtKB/TrEMBL
      G2W9L4, N1P8P2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38313.1

    Gene LinkOut

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