Tet2 tet methylcytosine dioxygenase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tet2provided by MGI
Official Full Name: tet methylcytosine dioxygenase 2provided by MGI
Primary source: MGI:MGI:2443298
See related: Ensembl:ENSMUSG00000040943 AllianceGenome:MGI:2443298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ayu17-449; mKIAA1546; E130014J05Rik
Summary: Enables 5-methylcytosine dioxygenase activity. Involved in myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; and protein O-linked glycosylation. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid progenitor cell differentiation; and positive regulation of gene expression, epigenetic. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; immune system; lower urogenital tract; and reproductive system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 4.9), CNS E11.5 (RPKM 4.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 61.84 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (133169438..133250882, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (133463677..133545136, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA m[5]C oxidation by TET2 regulates chromatin state and leukaemogenesis.
Title: RNA m(5)C oxidation by TET2 regulates chromatin state and leukaemogenesis.
Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes.
Title: Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes.
Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion.
Title: Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion.
Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function.
Title: Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function.
GID complex regulates the differentiation of neural stem cells by destabilizing TET2.
Title: GID complex regulates the differentiation of neural stem cells by destabilizing TET2.
Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity.
Title: Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity.
Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.
Title: Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.
DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell.
Title: DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell.
Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions.
Title: Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions.
A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.
Title: A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.

Submit: New GeneRIF Correction See all GeneRIFs (206)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Gene trapped (2) 1 citation
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234827

45.MMHAP66FLG6.seq (e-PCR)
- UniSTS:124586

Tet2 (e-PCR), detects polymorphism
- UniSTS:531425

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5-methylcytosine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-methylcytosine dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5-methylcytosine dioxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 5-methylcytosine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosomal 5-methylcytosine DNA demethylation, oxidation pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytosine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemoglobin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in leukocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within liver morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methylcytosine dioxygenase TET2

Names: probable methylcytosine dioxygenase TET2; tet oncogene 2; tet oncogene family member 2

NP_001035490.2

EC 1.14.11.80

NP_001333665.1

EC 1.14.11.80

XP_006501346.1

EC 1.14.11.80

XP_006501349.1

EC 1.14.11.80

XP_006501350.1

EC 1.14.11.80

XP_011238370.1

EC 1.14.11.80

XP_036018905.1

EC 1.14.11.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040400.2 → NP_001035490.2 methylcytosine dioxygenase TET2 isoform 1

See identical proteins and their annotated locations for NP_001035490.2

Status: VALIDATED

Source sequence(s)

AK129389, AK153311, BE137977, BF463367, DQ079067

Consensus CDS

CCDS51071.1

UniProtKB/Swiss-Prot

Q3U5R5, Q3U633, Q3UAI0, Q4JK59, Q6ZPN2, Q8K2K3

UniProtKB/TrEMBL

D0VLQ5

Related

ENSMUSP00000096203.4, ENSMUST00000098603.8

Conserved Domains (1) summary

pfam12851
Location:1203 → 1340

Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
NM_001346736.1 → NP_001333665.1 methylcytosine dioxygenase TET2 isoform 2

Status: VALIDATED

Source sequence(s)

AC120398, BF463367, DQ079067

Consensus CDS

CCDS84675.1

UniProtKB/TrEMBL

A0A0G2JF55, D0VLQ5

Related

ENSMUSP00000143029.2, ENSMUST00000196398.5

Conserved Domains (1) summary

cl40427
Location:1048 → 1373

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

133169438..133250882 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501283.5 → XP_006501346.1 methylcytosine dioxygenase TET2 isoform X1

See identical proteins and their annotated locations for XP_006501346.1

UniProtKB/TrEMBL

A0A0G2JF55, D0VLQ5

Conserved Domains (1) summary

cl40427
Location:1048 → 1373

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
XM_006501287.5 → XP_006501350.1 methylcytosine dioxygenase TET2 isoform X3

UniProtKB/TrEMBL

D0VLQ5

Conserved Domains (1) summary

cl40427
Location:1048 → 1364

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
XM_006501286.5 → XP_006501349.1 methylcytosine dioxygenase TET2 isoform X2

UniProtKB/TrEMBL

D0VLQ5

Conserved Domains (1) summary

cl40427
Location:1048 → 1372

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
XM_011240068.4 → XP_011238370.1 methylcytosine dioxygenase TET2 isoform X1

See identical proteins and their annotated locations for XP_011238370.1

UniProtKB/TrEMBL

A0A0G2JF55, D0VLQ5

Conserved Domains (1) summary

cl40427
Location:1048 → 1373

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
XM_036163012.1 → XP_036018905.1 methylcytosine dioxygenase TET2 isoform X1

UniProtKB/TrEMBL

A0A0G2JF55, D0VLQ5

Conserved Domains (1) summary

cl40427
Location:1048 → 1373

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_145989.1: Suppressed sequence

Description

NM_145989.1: This RefSeq was permanently suppressed based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.