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    Cab39l calcium binding protein 39-like [ Mus musculus (house mouse) ]

    Gene ID: 69008, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Cab39lprovided by MGI
    Official Full Name
    calcium binding protein 39-likeprovided by MGI
    Primary source
    MGI:MGI:1914081
    See related
    Ensembl:ENSMUSG00000021981 AllianceGenome:MGI:1914081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MO2L; 1500031K13Rik; 2810425O13Rik; 4930520C08Rik
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in intracellular signal transduction. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Orthologous to human CAB39L (calcium binding protein 39 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.1), testis adult (RPKM 7.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cab39l in Genome Data Viewer
    Location:
    14 C3; 14 31.48 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59678400..59786353)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59440934..59548904)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45935 Neighboring gene PHD finger protein 11C Neighboring gene SET domain, bifurcated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4112 Neighboring gene cytidine and dCMP deaminase domain containing 1 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36842 Neighboring gene ribosomal protein S9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinase Scaffold Cab39 Is Necessary for Phospho-Activation of the Thiazide-Sensitive NCC. Ferdaus MZ, et al. Hypertension, 2024 Apr. PMID 38258567,
    2. Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis. Lee S, et al. Cell Rep, 2024 May 28. PMID 38676926, Free PMC Article
    3. Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. Armfield BA, et al. J Urol, 2016 Oct. PMID 27173853, Free PMC Article
    4. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
    5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding protein 39-like
    Names
    MO25beta
    mo25-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360591.1 → NP_001347520.1  calcium-binding protein 39-like

      Status: VALIDATED

      Source sequence(s)
      AK030474, AK053642, AW122324, BQ562937, BY789575
      Consensus CDS
      CCDS27171.1
      UniProtKB/Swiss-Prot
      Q8BG52, Q91WB8, Q91YL0, Q9DB16
      Conserved Domains (1) summary
      pfam08569
      Location:6 → 333
      Mo25; Mo25-like

    2. NM_001360592.1 → NP_001347521.1  calcium-binding protein 39-like

      Status: VALIDATED

      Source sequence(s)
      AK030474, AK053642, AK076867, AW122324, BY789575
      Consensus CDS
      CCDS27171.1
      UniProtKB/Swiss-Prot
      Q8BG52, Q91WB8, Q91YL0, Q9DB16
      Conserved Domains (1) summary
      pfam08569
      Location:6 → 333
      Mo25; Mo25-like

    3. NM_001360593.1 → NP_001347522.1  calcium-binding protein 39-like

      Status: VALIDATED

      Source sequence(s)
      AK030474, AK053642, AW122324, CX563320
      Consensus CDS
      CCDS27171.1
      UniProtKB/Swiss-Prot
      Q8BG52, Q91WB8, Q91YL0, Q9DB16
      Conserved Domains (1) summary
      pfam08569
      Location:6 → 333
      Mo25; Mo25-like

    4. NM_026908.4 → NP_081184.3  calcium-binding protein 39-like

      See identical proteins and their annotated locations for NP_081184.3

      Status: VALIDATED

      Source sequence(s)
      AK030474, AK053642, AW122324, BY789575
      Consensus CDS
      CCDS27171.1
      UniProtKB/Swiss-Prot
      Q8BG52, Q91WB8, Q91YL0, Q9DB16
      Related
      ENSMUSP00000022553.6, ENSMUST00000022553.6
      Conserved Domains (1) summary
      pfam08569
      Location:6 → 333
      Mo25; Mo25-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      59678400..59786353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158837.1 → XP_036014730.1  calcium-binding protein 39-like isoform X1

      UniProtKB/Swiss-Prot
      Q8BG52, Q91WB8, Q91YL0, Q9DB16
      Conserved Domains (1) summary
      pfam08569
      Location:6 → 333
      Mo25; Mo25-like

    2. XM_036158838.1 → XP_036014731.1  calcium-binding protein 39-like isoform X1

      UniProtKB/Swiss-Prot
      Q8BG52, Q91WB8, Q91YL0, Q9DB16
      Conserved Domains (1) summary
      pfam08569
      Location:6 → 333
      Mo25; Mo25-like

    3. XM_017316177.3 → XP_017171666.1  calcium-binding protein 39-like isoform X2

      Conserved Domains (1) summary
      pfam08569
      Location:6 → 313
      Mo25; Mo25-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB16.3 GenPept UniProtKB/Swiss-Prot:Q9DB16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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