Pde2a phosphodiesterase 2A, cGMP-stimulated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde2aprovided by MGI
Official Full Name: phosphodiesterase 2A, cGMP-stimulatedprovided by MGI
Primary source: MGI:MGI:2446107
See related: Ensembl:ENSMUSG00000030653 Ensembl:ENSMUSG00000110195 AllianceGenome:MGI:2446107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cGSPDE; CGS-PDE
Summary: Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; GAF domain binding activity; and cyclic nucleotide binding activity. Involved in several processes, including cGMP catabolic process; cellular response to mechanical stimulus; and negative regulation of cGMP-mediated signaling. Acts upstream of or within circulatory system development and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and sensory organ. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.57 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101070905..101162026)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (101421691..101512829)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress.
Title: Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress.
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a.
Title: Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a.
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.
Title: The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.
Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression.
Title: Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression.
PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria.
Title: PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria.
Pde2A is indispensable for heart development because Pde2A knockout embryos show severe atria and ventricular defects.
Title: Critical role of phosphodiesterase 2A in mouse congenital heart defects.
Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by PDE2A.
Title: Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.
Effect of PDE2 inhibition on stress-induced memory impairment is potentially mediated via modulation of neuroplasticity-related NMDAR-CaMKII-cGMP/cAMP signaling.
Title: Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress.
We conclude that increased AM PDE2A is an important negative regulator of macrophage iNOS expression.
Title: Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages.
results demonstrate strong presynaptic inhibition by natriuretic peptides in the brain and suggest important physiological and behavioral roles of PDE2A in modulating neurotransmitter release
Title: Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_12039-12040:1004039373:1 (e-PCR)
- UniSTS:267315

UniSTS:235724 (e-PCR)
- UniSTS:235724

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3',5'-cyclic-GMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables GAF domain binding	IDA Inferred from Direct Assay more info	PubMed
enables TPR domain binding	ISO Inferred from Sequence Orthology more info
enables cAMP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cGMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cGMP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cGMP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cGMP-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cGMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to macrophage colony-stimulating factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart valve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cGMP-dependent 3',5'-cyclic phosphodiesterase

Names: cyclic GMP-stimulated phosphodiesterase

NP_001008548.1

EC 3.1.4.17

NP_001137320.1

EC 3.1.4.17

NP_001137321.1

EC 3.1.4.17

NP_001230686.1

EC 3.1.4.17

NP_001230687.1

EC 3.1.4.17

NP_001407472.1

EC 3.1.4.17

NP_001407473.1

EC 3.1.4.17

NP_001407474.1

EC 3.1.4.17

NP_001407475.1

EC 3.1.4.17

NP_001407477.1

EC 3.1.4.17

NP_001407478.1

EC 3.1.4.17

NP_001407479.1

EC 3.1.4.17

XP_006507586.1

EC 3.1.4.17

XP_006507587.1

EC 3.1.4.17

XP_006507589.1

EC 3.1.4.17

XP_006507592.1

EC 3.1.4.17

XP_030098167.1

EC 3.1.4.17

XP_036008744.1

EC 3.1.4.17

XP_036008745.1

EC 3.1.4.17

XP_036008746.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008548.5 → NP_001008548.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3

See identical proteins and their annotated locations for NP_001008548.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A3 (see, PMID:19632989) is shorter, compared to isoform 6.

Source sequence(s)

AC129079, AC129609

Consensus CDS

CCDS40043.1

UniProtKB/TrEMBL

Q3TYK5, Q5PR72

Related

ENSMUSP00000147847.2, ENSMUST00000211368.2

Conserved Domains (2) summary

smart00065
Location:404 → 553

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:650 → 883

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001143848.3 → NP_001137320.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6

See identical proteins and their annotated locations for NP_001137320.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform (6).

Source sequence(s)

AC129079, AC129609

Consensus CDS

CCDS52330.1

UniProtKB/Swiss-Prot

Q3TCR8, Q3TXZ6, Q8K2U1, Q922S4

UniProtKB/TrEMBL

Q3TYK5

Related

ENSMUSP00000131553.3, ENSMUST00000163751.10

Conserved Domains (2) summary

smart00065
Location:408 → 557

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:654 → 884

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001143849.3 → NP_001137321.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2

See identical proteins and their annotated locations for NP_001137321.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter, has a distinct 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A2 (see PMID:21724846) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 6.

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

Q3TD37

Conserved Domains (2) summary

smart00065
Location:397 → 546

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:643 → 876

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001243757.2 → NP_001230686.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

See identical proteins and their annotated locations for NP_001230686.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform, PDE2A1 (see PMID:19632989) is shorter and has a distinct N-terminus, compared to isoform 6.

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

F7D3W5

Related

ENSMUSP00000081956.9, ENSMUST00000084894.15

Conserved Domains (2) summary

smart00065
Location:385 → 534

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:631 → 864

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001243758.2 → NP_001230687.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 6.

Source sequence(s)

AC129079, AC129609

Consensus CDS

CCDS85351.1

UniProtKB/TrEMBL

A0A1B0GRJ9, Q3TYK5

Related

ENSMUSP00000147553.2, ENSMUST00000209537.2

Conserved Domains (2) summary

smart00065
Location:414 → 563

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:660 → 893

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001420543.1 → NP_001407472.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

Status: VALIDATED

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

F7D3W5
NM_001420544.1 → NP_001407473.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 7

Status: VALIDATED

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

Q3TD37
NM_001420545.1 → NP_001407474.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 8

Status: VALIDATED

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

F7D3W5
NM_001420546.1 → NP_001407475.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 8

Status: VALIDATED

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

F7D3W5
NM_001420548.1 → NP_001407477.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 9

Status: VALIDATED

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

Q3TYK5
NM_001420549.1 → NP_001407478.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 10

Status: VALIDATED

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

Q3TYK5
NM_001420550.1 → NP_001407479.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 11

Status: VALIDATED

Source sequence(s)

AC129079, AC129609

UniProtKB/TrEMBL

Q3TD37

RNA

NR_152193.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC129079, AC129609

Related

ENSMUST00000210364.2
NR_152194.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC129079, AC129609

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

101070905..101162026

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152852.1 → XP_036008745.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

UniProtKB/TrEMBL

F7D3W5

Conserved Domains (2) summary

smart00065
Location:389 → 538

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:635 → 868

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_006507524.3 → XP_006507587.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2

UniProtKB/TrEMBL

Q3TYK5

Conserved Domains (2) summary

smart00065
Location:418 → 567

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:664 → 897

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_006507526.3 → XP_006507589.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

See identical proteins and their annotated locations for XP_006507589.1

UniProtKB/TrEMBL

F7D3W5

Conserved Domains (2) summary

smart00065
Location:389 → 538

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:635 → 868

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_036152853.1 → XP_036008746.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X4

UniProtKB/TrEMBL

Q3TYK5

Conserved Domains (2) summary

smart00065
Location:386 → 535

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:632 → 865

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_036152851.1 → XP_036008744.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

UniProtKB/TrEMBL

F7D3W5

Conserved Domains (2) summary

smart00065
Location:389 → 538

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:635 → 868

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_030242307.2 → XP_030098167.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X5

UniProtKB/TrEMBL

F7D3W5

Conserved Domains (2) summary

smart00065
Location:385 → 534

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:631 → 864

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_006507529.3 → XP_006507592.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X6

See identical proteins and their annotated locations for XP_006507592.1

UniProtKB/TrEMBL

Q3TYK5

Conserved Domains (2) summary

smart00065
Location:268 → 417

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:514 → 747

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_006507523.3 → XP_006507586.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1

UniProtKB/TrEMBL

Q3TYK5

Conserved Domains (2) summary

smart00065
Location:422 → 571

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:668 → 901

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase