Zdhhc12 zinc finger, DHHC domain containing 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc12provided by MGI
Official Full Name: zinc finger, DHHC domain containing 12provided by MGI
Primary source: MGI:MGI:1913470
See related: Ensembl:ENSMUSG00000015335 AllianceGenome:MGI:1913470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1190004A01Rik
Summary: Enables protein-cysteine S-palmitoyltransferase activity. Involved in gephyrin clustering involved in postsynaptic density assembly; peptidyl-L-cysteine S-palmitoylation; and positive regulation of GABAergic synaptic transmission. Located in Golgi apparatus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZDHHC12 (zinc finger DHHC-type palmitoyltransferase 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 53.0), testis adult (RPKM 52.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (29980956..29983647, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30090943..30093638, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy.
Title: Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in gephyrin clustering involved in postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-L-cysteine S-palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC12

Names: DHHC domain-containing cysteine-rich protein 12; DHHC-12; probable palmitoyltransferase ZDHHC12; zinc finger DHHC domain-containing protein 12

NP_001032851.1

EC 2.3.1.225

NP_079704.2

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.