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    Igsf3 immunoglobulin superfamily, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 78908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igsf3provided by MGI
    Official Full Name
    immunoglobulin superfamily, member 3provided by MGI
    Primary source
    MGI:MGI:1926158
    See related
    Ensembl:ENSMUSG00000042035 AllianceGenome:MGI:1926158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0466; 1700016K10Rik; 2810035F16Rik; 4833439O17Rik
    Summary
    Predicted to be involved in lacrimal gland development. Predicted to be active in membrane. Is expressed in dorsal root ganglion; lung; and spinal cord. Human ortholog(s) of this gene implicated in lacrimal duct obstruction. Orthologous to human IGSF3 (immunoglobulin superfamily member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.2), limb E14.5 (RPKM 8.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Igsf3 in Genome Data Viewer
    Location:
    3 F2.2; 3 44.3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (101284306..101370375)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101376672..101463060)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08527 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_08529 Neighboring gene STARR-seq mESC enhancer starr_08530 Neighboring gene predicted gene, 32900 Neighboring gene VISTA enhancer mm1505 Neighboring gene STARR-seq mESC enhancer starr_08533 Neighboring gene STARR-seq mESC enhancer starr_08536 Neighboring gene STARR-seq mESC enhancer starr_08538 Neighboring gene STARR-seq mESC enhancer starr_08539 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101298216-101298417 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101301424-101301635 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101306075-101306330 Neighboring gene STARR-seq mESC enhancer starr_08540 Neighboring gene predicted gene, 40109 Neighboring gene predicted gene, 33162

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis. Usardi A, et al. Dev Neurobiol, 2017 Jan. PMID 27328461
    2. Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Penha-Gonçalves C, et al. Diabetes, 2003 Jun. PMID 12765969
    3. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization. Tanjore Ramanathan J, et al. Sci Rep, 2023 Oct 11. PMID 37821496, Free PMC Article
    4. Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10. Yamaji K, et al. Biochem Biophys Res Commun, 2005 Jun 3. PMID 15850792
    5. Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression. Pan Y, et al. Sci Rep, 2016 Oct 24. PMID 27775065, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.
      Title: Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.
    2. IGSF3 is a novel regulator of neuronal morphogenesis that might function through interactions with multiple partners.
      Title: The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lacrimal gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404406.1 → NP_001391335.1  immunoglobulin superfamily member 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131184

    2. NM_001404407.1 → NP_001391336.1  immunoglobulin superfamily member 3 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131184
      UniProtKB/TrEMBL
      A0A0A6YX40
      Related
      ENSMUSP00000141823.2, ENSMUST00000195164.2

    3. NM_001404408.1 → NP_001391337.1  immunoglobulin superfamily member 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131184

    4. NM_207205.3 → NP_997088.2  immunoglobulin superfamily member 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_997088.2

      Status: VALIDATED

      Source sequence(s)
      AC131184
      Consensus CDS
      CCDS17682.1
      UniProtKB/Swiss-Prot
      A0A4X9, Q6ZQA6, Q7TPV3
      Related
      ENSMUSP00000048900.6, ENSMUST00000043983.11
      Conserved Domains (3) summary
      smart00410
      Location:293 → 389
      IG_like; Immunoglobulin like
      pfam07686
      Location:687 → 784
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:162 → 256
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      101284306..101370375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502343.5 → XP_006502406.1  immunoglobulin superfamily member 3 isoform X1

      See identical proteins and their annotated locations for XP_006502406.1

      UniProtKB/TrEMBL
      A0A0A6YX40
      Conserved Domains (3) summary
      smart00409
      Location:293 → 389
      IG; Immunoglobulin
      pfam07686
      Location:707 → 804
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:162 → 256
      Ig; Immunoglobulin domain

    2. XM_030252915.2 → XP_030108775.1  immunoglobulin superfamily member 3 isoform X3

      UniProtKB/Swiss-Prot
      A0A4X9, Q6ZQA6, Q7TPV3
      Conserved Domains (3) summary
      smart00410
      Location:293 → 389
      IG_like; Immunoglobulin like
      pfam07686
      Location:687 → 784
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:162 → 256
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQA6.2 GenPept UniProtKB/Swiss-Prot:Q6ZQA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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