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    NR2F2-AS1 NR2F2 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 644192, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NR2F2-AS1provided by HGNC
    Official Full Name
    NR2F2 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:44222
    See related
    Ensembl:ENSG00000247809 AllianceGenome:HGNC:44222
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in ovary (RPKM 4.1), endometrium (RPKM 2.2) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NR2F2-AS1 in Genome Data Viewer
    Location:
    15q26.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (96127360..96327361, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (93891941..94091945, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (96670589..96870590, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903582 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:96453692-96454619 Neighboring gene NANOG hESC enhancer GRCh37_chr15:96454690-96455312 Neighboring gene CRISPRi-validated cis-regulatory element chr15.3490 Neighboring gene uncharacterized LOC112268156 Neighboring gene uncharacterized LOC105370998 Neighboring gene uncharacterized LOC105369212 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:96630222-96630743 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:96678081-96679280 Neighboring gene uncharacterized LOC124903583 Neighboring gene uncharacterized LOC105370997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:96723470-96723970 Neighboring gene NANOG hESC enhancer GRCh37_chr15:96726277-96726778 Neighboring gene uncharacterized LOC124903584 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:96794933-96796132 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:96811550-96812164 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:96816434-96817633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:96876956-96877918 Neighboring gene Sharpr-MPRA regulatory region 11279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:96884589-96885109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:96885110-96885629 Neighboring gene uncharacterized LOC101927263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:96897481-96898380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:96901703-96902545 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:96905583-96906432 Neighboring gene microRNA 1469 Neighboring gene nuclear receptor subfamily 2 group F member 2 Neighboring gene tubulin alpha pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA NR2F2-AS1 inhibits the progression of oral squamous cell carcinoma by mediating the miR-32-5p/SEMA3A axis. Qin SY, et al. Kaohsiung J Med Sci, 2024 Oct. PMID 39177014
    2. Long non-coding RNA NR2F2-AS1: its expanding oncogenic roles in tumor progression. Ghorbanzadeh S, et al. Hum Cell, 2022 Sep. PMID 35796938
    3. lncRNA NR2F2-AS1 inhibits the methylation of miR-494 to regulate oral squamous cell carcinoma cell proliferation. Liang Y, et al. Arch Oral Biol, 2022 Feb. PMID 34896865
    4. NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer. Liu D, et al. Biosci Rep, 2020 Jun 26. PMID 32469064, Free PMC Article
    5. Downregulation of long non-coding RNA NR2F2-AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN. Qin H, et al. Oncol Lett, 2020 Feb. PMID 31966043, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA NR2F2-AS1 inhibits the progression of oral squamous cell carcinoma by mediating the miR-32-5p/SEMA3A axis.
      Title: LncRNA NR2F2-AS1 inhibits the progression of oral squamous cell carcinoma by mediating the miR-32-5p/SEMA3A axis.
    2. Long non-coding RNA NR2F2-AS1 regulates human osteosarcoma growth and metastasis through miR-425-5p-mediated HMGB2.
      Title: Long non-coding RNA NR2F2-AS1 regulates human osteosarcoma growth and metastasis through miR-425-5p-mediated HMGB2.
    3. Long non-coding RNA NR2F2-AS1: its expanding oncogenic roles in tumor progression.
      Title: Long non-coding RNA NR2F2-AS1: its expanding oncogenic roles in tumor progression.
    4. lncRNA NR2F2-AS1 inhibits the methylation of miR-494 to regulate oral squamous cell carcinoma cell proliferation.
      Title: lncRNA NR2F2-AS1 inhibits the methylation of miR-494 to regulate oral squamous cell carcinoma cell proliferation.
    5. LncRNA NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in prostate carcinoma.
      Title: LncRNA NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in prostate carcinoma.
    6. The miR-106b/NR2F2-AS1/PLEKHO2 Axis Regulates Migration and Invasion of Colorectal Cancer through the MAPK Pathway.
      Title: The miR-106b/NR2F2-AS1/PLEKHO2 Axis Regulates Migration and Invasion of Colorectal Cancer through the MAPK Pathway.
    7. NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer.
      Title: NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer.
    8. Downregulation of NR2F2-AS1 induces G1 arrest of colorectal cancer cells by downregulating CDK6.
      Title: Downregulation of lncRNA NR2F2 Antisense RNA 1 Induces G1 Arrest of Colorectal Cancer Cells by Downregulating Cyclin-Dependent Kinase 6.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
    EBI GWAS Catalog
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • NR2F2 antisense RNA 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_102743.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC012409, AK307134, CF528780, DA627574
      Related
      ENST00000743199.1

    2. NR_102744.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons and its transcription extends past a splice site used in variant 1, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AW451632, CB217374, DA627574
      Related
      ENST00000560010.1

    3. NR_125738.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' terminal exon, lacks multiple 3' exons, and contains three alternate 3' exons, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC012409, BI758289, DA941342
      Related
      ENST00000560800.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      96127360..96327361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      93891941..94091945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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