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    VTC1 Vtc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VTC1
    Official Full Name
    Vtc1p
    Primary source
    SGD:S000000874
    Locus tag
    YER072W
    See related
    AllianceGenome:SGD:S000000874; FungiDB:YER072W; VEuPathDB:YER072W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NRF1; PHM4
    Summary
    Enables mRNA binding activity. Involved in several processes, including microautophagy; polyphosphate biosynthetic process; and vacuole fusion, non-autophagic. Located in endoplasmic reticulum; nuclear membrane; and vacuolar membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VTC1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (302806..303195)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribonucleotide-diphosphate reductase subunit RNR1 Neighboring gene Tda2p Neighboring gene aldehyde dehydrogenase (NAD(P)(+)) ALD5 Neighboring gene ribosomal 40S subunit protein S24A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ddi1 is a ubiquitin-dependent protease. Yip MCJ, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32193351, Free PMC Article
    2. Role of the Vtc proteins in V-ATPase stability and membrane trafficking. Müller O, et al. J Cell Sci, 2003 Mar 15. PMID 12584253
    3. The function of Spt3, a subunit of the SAGA complex, in PGK1 transcription is restored only partially when reintroduced by plasmid into taf1 spt3 double mutant yeast strains. Iwami R, et al. Genes Genet Syst, 2020 Aug 27. PMID 32624556
    4. Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Hothorn M, et al. Science, 2009 Apr 24. PMID 19390046
    5. Coupled synthesis and translocation restrains polyphosphate to acidocalcisome-like vacuoles and prevents its toxicity. Gerasimaitė R, et al. J Cell Sci, 2014 Dec 1. PMID 25315834

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vtc1p
    NP_010995.1
    • Regulatory subunit of vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      302806..303195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178963.1 → NP_010995.1  TPA: Vtc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010995.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLX7, P40046
      UniProtKB/TrEMBL
      A6ZR26, B3LRI9, C7GRQ4, C8Z780, G2WCW1, N1P6Z8
      Conserved Domains (1) summary
      COG5264
      Location:1 → 124
      VTC1; Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40046.3

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