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    GCG1 gamma-glutamylcyclotransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCG1
    Official Full Name
    gamma-glutamylcyclotransferase
    Primary source
    SGD:S000000965
    Locus tag
    YER163C
    See related
    AllianceGenome:SGD:S000000965; FungiDB:YER163C; VEuPathDB:YER163C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables gamma-glutamylcyclotransferase activity. Involved in glutathione catabolic process. Located in cytoplasm and nucleus. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) and CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GCG1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (503084..503782, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Spt2p Neighboring gene Rad4p Neighboring gene chromatin-remodeling ATPase CHD1 Neighboring gene polyadenylate-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Tu BP, et al. Science, 2005 Nov 18. PMID 16254148
    2. ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. Kaur A, et al. J Biol Chem, 2017 Jan 13. PMID 27913623, Free PMC Article
    3. Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. Kumar A, et al. EMBO Rep, 2012 Dec. PMID 23070364, Free PMC Article
    4. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article
    5. Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions. den Brave F, et al. Cell Rep, 2020 Jun 2. PMID 32492414, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables gamma-glutamylcyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione specific gamma-glutamylcyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamylcyclotransferase
    NP_011090.3
    • Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      503084..503782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179053.3 → NP_011090.3  TPA: gamma-glutamylcyclotransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011090.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM71, P32656
      UniProtKB/TrEMBL
      A6ZRB9, B3LRS4, C7GS47, C8Z7I5, G2WD49, N1P3P1
      Conserved Domains (1) summary
      pfam04752
      Location:8 → 231
      ChaC; ChaC-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32656.1

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