Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
CD1d surface expression on human cell lines is downregulated after infection with M-tropic HIV, T-tropic HIV, or after exposure to HIV gp120 in vitro |
PubMed
|
Nef
|
nef
|
HIV-1 Nef downregulates the expression of the non-classical MHC-I like CD1d molecule by increasing internalization of CD1d molecules from the cell surface and retaining CD1d in the trans-Golgi-network (TGN) |
PubMed
|
|
nef
|
HIV-1 Vpu and Nef cooperatively inhibit CD1d-mediated lipid antigen presentation in HIV-1-infected DCs |
PubMed
|
|
nef
|
Nef-induced downregulation of CD1d is observed when cells are co-expressing Nef and CD1d, and six amino acids (300-305) in the cytoplasmic tail of CD1d are required for the downregulation by Nef |
PubMed
|
|
nef
|
HIV-1 Nef-mediated downregulation of CD1d requires a tyrosine-based motif in the CD1d cytoplasmic tail and four Nef amino acid motifs (EEEE65, PxxP75, DD165, and LL175), which are known to be involved in the downregulation of MHC-I and CD4 |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr downregulates the expression of CD1D in human monocyte-derived dendritic cells |
PubMed
|
Vpu
|
vpu
|
The conserved APW motif in the alpha-helix II domain at the C-terminal region of HIV-1 Vpu is involved in CD1d downregulation |
PubMed
|
|
vpu
|
HIV-1 Vpu proteins from group M, O, and P, and SIV Vpu proteins efficiently downregulate CD1d surface levels |
PubMed
|
|
vpu
|
HIV-1 Vpu downregulates CD1d from the cell surface by inhibiting CD1d recycling from early endosomal compartments to the cell surface |
PubMed
|
|
vpu
|
HIV-1 Vpu proteins from Cameroonian group N viruses are largely unable to downregulate CD1D |
PubMed
|
|
vpu
|
HIV-1 Vpu and Nef cooperatively inhibit CD1d-mediated lipid antigen presentation in HIV-1-infected DCs |
PubMed
|
Go to the HIV-1, Human Interaction Database