H2BC26 H2B clustered histone 26 [Homo sapiens (human)] - Gene

Summary

Official Symbol: H2BC26provided by HGNC
Official Full Name: H2B clustered histone 26provided by HGNC
Primary source: HGNC:HGNC:20514
See related: Ensembl:ENSG00000196890 MIM:615046; AllianceGenome:HGNC:20514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H2Bb; H2BU1; HIST3H2BB
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs: all
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Genomic context

Location:: 1q42.13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (228458103..228458558)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (227646615..227647070)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (228645804..228646259)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATM-dependent monoubiquitylation of histone H2B is required for timely repair of DNA double-strand breaks
Title: Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.
The present findings provide evidence indicating that the extrachromosomal histone H2B is engaged in the signaling pathway initiated by dsDNA to trigger antiviral innate immune responses.
Title: Extrachromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA.
USP7 can stimulate EBNA1-DNA interactions and EBNA1 can alter histone modification at oriP through recruitment of USP7.
Title: EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication.
infertile men have a higher proportion of spermatozoa with diffuse histone H2B
Title: Sperm nuclear histone H2B: correlation with sperm DNA denaturation and DNA stainability.
Histone H2B represents a regulated plasminogen receptor, which contributes significantly to the plasminogen binding capacity of cells.
Title: Identification of histone H2B as a regulated plasminogen receptor.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, histone 3 H2bb, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa	PubMed
Tat	tat	HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hist1h2bc (e-PCR), detects polymorphism
- UniSTS:259084

RH103220 (e-PCR)
- UniSTS:97553

GDB:434012 (e-PCR)
- UniSTS:157204

RH68905 (e-PCR)
- UniSTS:79657

NoName (e-PCR)
- UniSTS:482609

D8S2279 (e-PCR)
- UniSTS:473907

HIST3H2BB__6568 (e-PCR)
- UniSTS:464491

SHGC-76465 (e-PCR)
- UniSTS:19051

D1S1423 (e-PCR)
- UniSTS:149619

G30966 (e-PCR)
- UniSTS:8586

D11S3114 (e-PCR)
- UniSTS:152207

NoName (e-PCR)
- UniSTS:481460

L17971 (e-PCR)
- UniSTS:43966

D11S2875 (e-PCR)
- UniSTS:152053

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H2B type 3-B

Names: H2B type 12; H2B.U histone 1; histone 3, H2bb; histone cluster 3 H2B family member b; histone cluster 3, H2bb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.