ZCCHC24 zinc finger CCHC-type containing 24 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZCCHC24provided by HGNC
Official Full Name: zinc finger CCHC-type containing 24provided by HGNC
Primary source: HGNC:HGNC:26911
See related: Ensembl:ENSG00000165424 AllianceGenome:HGNC:26911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Z3CXXC8; C10orf56
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in brain (RPKM 26.2), fat (RPKM 23.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (79382325..79445624, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (80251666..80314699, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (81142081..81205380, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A004Y13 (e-PCR)
- UniSTS:3896

A006U24 (e-PCR)
- UniSTS:55904

STS-AA040726 (e-PCR)
- UniSTS:67432

WI-12518 (e-PCR)
- UniSTS:61327

D10S1550E (e-PCR)
- UniSTS:153774

RH104155 (e-PCR)
- UniSTS:98480

STS-Z41445 (e-PCR)
- UniSTS:26077

D10S314 (e-PCR)
- UniSTS:147951

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger CCHC domain-containing protein 24

Names: zinc finger, 3CxxC-type 8; zinc finger, CCHC domain containing 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153367.4 → NP_699198.2 zinc finger CCHC domain-containing protein 24

See identical proteins and their annotated locations for NP_699198.2

Status: VALIDATED

Source sequence(s)

AL133481, BC053564

Consensus CDS

CCDS7359.1

UniProtKB/Swiss-Prot

Q5U5T9, Q8N2G6, Q8TAG0

Related

ENSP00000361411.3, ENST00000372336.4

Conserved Domains (2) summary

COG5222
Location:33 → 157

COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

pfam17180
Location:164 → 230

zf-3CxxC_2; Zinc-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

79382325..79445624 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011539452.4 → XP_011537754.1 zinc finger CCHC domain-containing protein 24 isoform X1

See identical proteins and their annotated locations for XP_011537754.1

Conserved Domains (2) summary

pfam13695
Location:95 → 161

zf-3CxxC; Zinc-binding domain

pfam13696
Location:59 → 79

zf-CCHC_2; Zinc knuckle

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

80251666..80314699 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054364999.1 → XP_054220974.1 zinc finger CCHC domain-containing protein 24 isoform X1
XM_054365000.1 → XP_054220975.1 zinc finger CCHC domain-containing protein 24 isoform X2