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    PRM6 pheromone-regulated K(+) transporter PRM6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRM6
    Official Full Name
    pheromone-regulated K(+) transporter PRM6
    Primary source
    SGD:S000004510
    Locus tag
    YML047C
    See related
    AllianceGenome:SGD:S000004510; FungiDB:YML047C; VEuPathDB:YML047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KCH2
    Summary
    Enables potassium ion transmembrane transporter activity. Involved in potassium ion transmembrane transport. Located in cellular bud tip; mating projection tip; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRM6 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (180017..181075, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit RSE1 Neighboring gene Gsf2p Neighboring gene Prp39p Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kch1 family proteins mediate essential responses to endoplasmic reticulum stresses in the yeasts Saccharomyces cerevisiae and Candida albicans. Stefan CP, et al. J Biol Chem, 2013 Nov 29. PMID 24142703, Free PMC Article
    2. Yeast Kch1 and Kch2 membrane proteins play a pleiotropic role in membrane potential establishment and monovalent cation homeostasis regulation. Felcmanova K, et al. FEMS Yeast Res, 2017 Aug 1. PMID 28810704
    3. Activation of an essential calcium signaling pathway in Saccharomyces cerevisiae by Kch1 and Kch2, putative low-affinity potassium transporters. Stefan CP, et al. Eukaryot Cell, 2013 Feb. PMID 23204190, Free PMC Article
    4. The mating response cascade does not modulate changes in the steady-state level of target mRNAs through control of mRNA stability. Kitchen CM, et al. Yeast, 2009 May. PMID 19319831
    5. Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. Heiman MG, et al. J Cell Biol, 2000 Oct 30. PMID 11062271, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate that the Kch1 and Kch2 proteins significantly contribute to the maintenance of optimal cation homeostasis and membrane potential in Saccharomyces cerevisiae but not in Candida albicans.
      Title: Yeast Kch1 and Kch2 membrane proteins play a pleiotropic role in membrane potential establishment and monovalent cation homeostasis regulation.
    2. Kch1 and Kch2 directly promote potassium influx and calcium signaling may electrochemically respond to potassium influx.
      Title: Activation of an essential calcium signaling pathway in Saccharomyces cerevisiae by Kch1 and Kch2, putative low-affinity potassium transporters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables potassium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pheromone-regulated K(+) transporter PRM6
    NP_013666.1
    • Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog, KCH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      180017..181075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182404.1 → NP_013666.1  TPA: pheromone-regulated K(+) transporter PRM6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZC8, Q04705
      UniProtKB/TrEMBL
      A6ZM20, B3LLL0, C7GS63, C8ZEG2, G2WK10, N1NXZ1
      Conserved Domains (1) summary
      pfam16944
      Location:9 → 231
      KCH; Fungal potassium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04705.1

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