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    Mroh7 maestro heat-like repeat family member 7 [ Mus musculus (house mouse) ]

    Gene ID: 381538, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Mroh7provided by MGI
    Official Full Name
    maestro heat-like repeat family member 7provided by MGI
    Primary source
    MGI:MGI:2685873
    See related
    Ensembl:ENSMUSG00000047502 AllianceGenome:MGI:2685873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1027; Heatr8
    Summary
    Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human MROH7 (maestro heat like repeat family member 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in testis adult (RPKM 58.4) and large intestine adult (RPKM 2.6) See more
    Orthologs
    human all
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    Genomic context

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    See Mroh7 in Genome Data Viewer
    Location:
    4 C7; 4 49.69 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106537614..106595059, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106680417..106736534, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2700 Neighboring gene prolyl-tRNA synthetase (mitochondrial)(putative) Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene STARR-positive B cell enhancer ABC_E6195 Neighboring gene family with sequence simliarity 151, member A Neighboring gene acyl-CoA thioesterase 11 Neighboring gene STARR-positive B cell enhancer ABC_E4640 Neighboring gene predicted gene, 31065

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. Suzuki A, et al. J Reprod Immunol, 2024 Jun. PMID 38697008,
    2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maestro heat-like repeat-containing protein family member 7
    Names
    HEAT repeat-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126487.1 → NP_001119959.1  maestro heat-like repeat-containing protein family member 7

      Status: VALIDATED

      Source sequence(s)
      AL929585
      Consensus CDS
      CCDS51253.1
      UniProtKB/Swiss-Prot
      A2AVR2
      Related
      ENSMUSP00000102382.2, ENSMUST00000106770.8
      Conserved Domains (1) summary
      pfam06566
      Location:26 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      106537614..106595059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240561.4 → XP_011238863.1  maestro heat-like repeat-containing protein family member 7 isoform X1

      UniProtKB/Swiss-Prot
      A2AVR2
      Conserved Domains (1) summary
      pfam06566
      Location:26 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    2. XM_011240562.3 → XP_011238864.1  maestro heat-like repeat-containing protein family member 7 isoform X1

      UniProtKB/Swiss-Prot
      A2AVR2
      Conserved Domains (1) summary
      pfam06566
      Location:26 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    3. XM_011240564.1 → XP_011238866.1  maestro heat-like repeat-containing protein family member 7 isoform X4

      Conserved Domains (1) summary
      pfam06566
      Location:26 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    4. XM_011240563.1 → XP_011238865.1  maestro heat-like repeat-containing protein family member 7 isoform X2

      Conserved Domains (1) summary
      pfam06566
      Location:26 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    5. XM_036164208.1 → XP_036020101.1  maestro heat-like repeat-containing protein family member 7 isoform X3

      Conserved Domains (1) summary
      PHA03307
      Location:15 → 168
      PHA03307; transcriptional regulator ICP4; Provisional

    6. XM_006503201.1 → XP_006503264.1  maestro heat-like repeat-containing protein family member 7 isoform X1

      UniProtKB/Swiss-Prot
      A2AVR2
      Conserved Domains (1) summary
      pfam06566
      Location:26 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    7. XM_011240565.1 → XP_011238867.1  maestro heat-like repeat-containing protein family member 7 isoform X5

      Conserved Domains (1) summary
      pfam06566
      Location:37 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain

    8. XM_011240566.3 → XP_011238868.1  maestro heat-like repeat-containing protein family member 7 isoform X6

      Conserved Domains (1) summary
      pfam06566
      Location:37 → 168
      Chon_Sulph_att; Chondroitin sulphate attachment domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AVR2.1 GenPept UniProtKB/Swiss-Prot:A2AVR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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