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    Dhrs9 dehydrogenase/reductase 9 [ Mus musculus (house mouse) ]

    Gene ID: 241452, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dhrs9provided by MGI
    Official Full Name
    dehydrogenase/reductase 9provided by MGI
    Primary source
    MGI:MGI:2442798
    See related
    Ensembl:ENSMUSG00000027068 AllianceGenome:MGI:2442798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdh15; C730025I08Rik
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in 9-cis-retinoic acid biosynthetic process; androgen metabolic process; and progesterone metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human DHRS9 (dehydrogenase/reductase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 6.0), colon adult (RPKM 1.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhrs9 in Genome Data Viewer
    Location:
    2 C2; 2 40.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69210806..69233430)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69380462..69403086)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphatase, catalytic, 2 Neighboring gene STARR-seq mESC enhancer starr_04731 Neighboring gene ATP-binding cassette, sub-family B member 11 Neighboring gene STARR-seq mESC enhancer starr_04732 Neighboring gene predicted gene, 36393 Neighboring gene STARR-seq mESC enhancer starr_04734 Neighboring gene STARR-seq mESC enhancer starr_04735 Neighboring gene low density lipoprotein receptor-related protein 2 Neighboring gene STARR-seq mESC enhancer starr_04736 Neighboring gene STARR-seq mESC enhancer starr_04740 Neighboring gene STARR-seq mESC enhancer starr_04741 Neighboring gene STARR-positive B cell enhancer ABC_E7822 Neighboring gene STARR-positive B cell enhancer ABC_E5928 Neighboring gene Bardet-Biedl syndrome 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substrates. Belyaeva OV, et al. J Biol Chem, 2022 Jan. PMID 34953854, Free PMC Article
    2. Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Driessen C, et al. Vision Res, 2003 Dec. PMID 14611944
    3. Short-chain dehydrogenases/reductases in retina. Haeseleer F, et al. Methods Enzymol, 2000. PMID 10800688
    4. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Chen S, et al. Proc Natl Acad Sci U S A, 2017 Feb 21. PMID 28167773, Free PMC Article
    5. Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands. Wu L, et al. J Biol Chem, 2019 Nov 8. PMID 31562240, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 9-cis-retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 9-cis-retinoic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in progesterone metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in progesterone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 9
    Names
    3-alpha hydroxysteroid dehydrogenase
    3-alpha-HSD
    3alpha-HSD
    dehydrogenase/reductase (SDR family) member 9
    epithelial retinol dehydrogenase
    retinol dehydrogenase
    short-chain dehydrogenase/reductase retSDR8
    NP_780721.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175512.2 → NP_780721.1  dehydrogenase/reductase SDR family member 9 precursor

      See identical proteins and their annotated locations for NP_780721.1

      Status: PROVISIONAL

      Source sequence(s)
      AK080914
      Consensus CDS
      CCDS16091.1
      UniProtKB/Swiss-Prot
      Q58NB6, Q8BGC7
      UniProtKB/TrEMBL
      Q148Q4
      Related
      ENSMUSP00000069631.4, ENSMUST00000063690.4
      Conserved Domains (1) summary
      cd09805
      Location:30 → 306
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69210806..69233430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58NB6.2 GenPept UniProtKB/Swiss-Prot:Q58NB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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