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    Fbxo48 F-box protein 48 [ Mus musculus (house mouse) ]

    Gene ID: 319701, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fbxo48provided by MGI
    Official Full Name
    F-box protein 48provided by MGI
    Primary source
    MGI:MGI:2442569
    See related
    Ensembl:ENSMUSG00000044966 AllianceGenome:MGI:2442569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630050E13Rik
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in axial skeleton; liver; midbrain ventricular layer; and telencephalon ventricular layer. Orthologous to human FBXO48 (F-box protein 48). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 2.1), liver E14.5 (RPKM 1.8) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo48 in Genome Data Viewer
    Location:
    11 A2; 11 9.41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16901225..16908516)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16951224..16954777)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor Neighboring gene predicted gene, 39584 Neighboring gene STARR-seq mESC enhancer starr_28696 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene pleckstrin Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene signal peptide, CUB domain, EGF-like 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 48
    Names
    novel F-box domain containing protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359162.1 → NP_001346091.1  F-box only protein 48

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK037835, AK041978
      Consensus CDS
      CCDS24445.1
      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Related
      ENSMUSP00000105263.2, ENSMUST00000109635.2
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    2. NM_176982.2 → NP_795956.1  F-box only protein 48

      See identical proteins and their annotated locations for NP_795956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK037835
      Consensus CDS
      CCDS24445.1
      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Related
      ENSMUSP00000057901.2, ENSMUST00000061327.2
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      16901225..16908516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514732.5 → XP_006514795.1  F-box only protein 48 isoform X1

      See identical proteins and their annotated locations for XP_006514795.1

      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    2. XM_006514731.5 → XP_006514794.1  F-box only protein 48 isoform X1

      See identical proteins and their annotated locations for XP_006514794.1

      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    3. XM_017314603.3 → XP_017170092.1  F-box only protein 48 isoform X1

      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    4. XM_006514728.5 → XP_006514791.1  F-box only protein 48 isoform X1

      See identical proteins and their annotated locations for XP_006514791.1

      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    5. XM_017314602.3 → XP_017170091.1  F-box only protein 48 isoform X1

      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    6. XM_017314604.3 → XP_017170093.1  F-box only protein 48 isoform X1

      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like

    7. XM_011243726.4 → XP_011242028.1  F-box only protein 48 isoform X1

      See identical proteins and their annotated locations for XP_011242028.1

      UniProtKB/Swiss-Prot
      Q8C9J8, Q8CAT8
      Conserved Domains (1) summary
      pfam12937
      Location:38 → 77
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CAT8.1 GenPept UniProtKB/Swiss-Prot:Q8CAT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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