HO Hop [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HO
Official Full Name: Hop
Primary source: SGD:S000002386
Locus tag: YDL227C
See related: AllianceGenome:SGD:S000002386; FungiDB:YDL227C; VEuPathDB:YDL227C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables endonuclease activity. Involved in gene conversion at mating-type locus. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HO in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (46271..48031, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family.
Title: The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family.
Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction.
Title: Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction.
Data show that mutation of the Rts1 regulatory subunit of PP2A phosphatase (PP2ARts1 phosphatase) results in decreased HO endonuclease expression due to altered localization of the Ace2 transcription factor.
Title: The Rts1 regulatory subunit of PP2A phosphatase controls expression of the HO endonuclease via localization of the Ace2 transcription factor.
Swi4/Swi6 (SBF) factor binding at HO follows a temporal cascade, with SBF bound at upstream regulatory sequence (URS2-L) serving to relay a signal from URS1 to the SBF sites in URS2-R that ultimately activate gene expression.
Title: Spatiotemporal cascade of transcription factor binding required for promoter activation.
HO promotor region fires in an "on/off" fashion in WT cells as well as in different genetic backgrounds.
Title: Stochastic expression and epigenetic memory at the yeast HO promoter.
Data show that coactivators bind first to far upstream promoter regions of HO and subsequently to a promoter proximal region, and FACT and Asf1 are both required for this coactivator re-recruitment.
Title: FACT and Asf1 regulate nucleosome dynamics and coactivator binding at the HO promoter.
Nuclear export of Ho endonuclease of yeast via Msn5
Title: Nuclear export of Ho endonuclease of yeast via Msn5.
Analysis of MATalpha2 and MATa1 binding sites on the HO promotor that mediate repression of the HO gene.
Title: Repression of the yeast HO gene by the MATalpha2 and MATa1 homeodomain proteins.
DDI1 participates in MEC1-mediated degradation of HO.
Title: The DNA damage-inducible UbL-UbA protein Ddi1 participates in Mec1-mediated degradation of Ho endonuclease.
ho endonuclease nuclear import utilizes two nuclear localization signals and four importins of the ribosomal import system
Title: Nuclear import of ho endonuclease utilizes two nuclear localization signals and four importins of the ribosomal import system.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in gene conversion at mating-type locus	IDA Inferred from Direct Assay more info	PubMed
involved_in intein-mediated protein splicing	IEA Inferred from Electronic Annotation more info
involved_in mating type switching	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hop

NP_010054.1

Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p, and Ash1p