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    Camk1g calcium/calmodulin-dependent protein kinase I gamma [ Mus musculus (house mouse) ]

    Gene ID: 215303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Camk1gprovided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase I gammaprovided by MGI
    Primary source
    MGI:MGI:2388073
    See related
    Ensembl:ENSMUSG00000016179 AllianceGenome:MGI:2388073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLICK III; CLICK-III; CaMKIgamma
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity. Predicted to be involved in signal transduction. Located in endomembrane system and plasma membrane. Part of calcium- and calmodulin-dependent protein kinase complex. Is expressed in several structures, including genitourinary system; heart; nervous system; and retina. Orthologous to human CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 15.3), whole brain E14.5 (RPKM 12.6) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Camk1g in Genome Data Viewer
    Location:
    1 H6; 1 97.74 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (193028654..193052636, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193346346..193370355, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene G0/G1 switch gene 2 Neighboring gene laminin, beta 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195164577-195164848 Neighboring gene predicted gene, 51741 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195273620-195273803 Neighboring gene VISTA enhancer mm935 Neighboring gene STARR-seq mESC enhancer starr_03474 Neighboring gene predicted gene, 38022 Neighboring gene predicted gene, 31753

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Takemoto-Kimura S, et al. Neuron, 2007 Jun 7. PMID 17553424
    2. Role of SODD in regulation of tumor necrosis factor responses. Takada H, et al. Mol Cell Biol, 2003 Jun. PMID 12748303, Free PMC Article
    3. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. Ageta-Ishihara N, et al. J Neurosci, 2009 Oct 28. PMID 19864584, Free PMC Article
    4. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). Takemoto-Kimura S, et al. J Biol Chem, 2003 May 16. PMID 12637513
    5. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. Pang ZP, et al. J Biol Chem, 2010 Oct 29. PMID 20729199, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons
      Title: Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
    2. CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
      Title: Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
    3. CL3 may represent a key element in the Ca(2+)-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons.
      Title: Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30513

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of calcium- and calmodulin-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1G
    Names
    caM kinase I gamma
    caM kinase IG
    caM-KI gamma
    caMK-like CREB kinase III
    caMKI gamma
    caMKIG
    NP_001408321.1
    NP_001408322.1
    NP_659066.1
    XP_030108815.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421392.1 → NP_001408321.1  calcium/calmodulin-dependent protein kinase type 1G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022675

    2. NM_001421393.1 → NP_001408322.1  calcium/calmodulin-dependent protein kinase type 1G isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022675
      Related
      ENSMUSP00000128143.2, ENSMUST00000169907.8

    3. NM_144817.3 → NP_659066.1  calcium/calmodulin-dependent protein kinase type 1G isoform 2

      See identical proteins and their annotated locations for NP_659066.1

      Status: VALIDATED

      Source sequence(s)
      AC022675
      Consensus CDS
      CCDS15638.1
      UniProtKB/Swiss-Prot
      Q91VB2
      Related
      ENSMUSP00000016323.5, ENSMUST00000016323.11
      Conserved Domains (2) summary
      smart00220
      Location:23 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14166
      Location:19 → 303
      STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      193028654..193052636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252955.2 → XP_030108815.1  calcium/calmodulin-dependent protein kinase type 1G isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 207
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VB2.1 GenPept UniProtKB/Swiss-Prot:Q91VB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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