U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rcn1 reticulocalbin 1 [ Mus musculus (house mouse) ]

    Gene ID: 19672, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rcn1provided by MGI
    Official Full Name
    reticulocalbin 1provided by MGI
    Primary source
    MGI:MGI:104559
    See related
    Ensembl:ENSMUSG00000005973 AllianceGenome:MGI:104559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rcn
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within camera-type eye development and in utero embryonic development. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; semicircular canal; spinal cord ventricular layer; and vertebral axis musculature. Orthologous to human RCN1 (reticulocalbin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 50.5), adrenal adult (RPKM 36.1) and 22 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rcn1 in Genome Data Viewer
    Location:
    2 E3; 2 55.18 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (105216293..105229664, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (105385948..105399319, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Wt1 promoter region Neighboring gene STARR-seq mESC enhancer starr_05304 Neighboring gene WT1 transcription factor Neighboring gene STARR-seq mESC enhancer starr_05306 Neighboring gene thioesterase superfamily member 7 Neighboring gene STARR-seq mESC enhancer starr_05307 Neighboring gene predicted gene, 39900 Neighboring gene RIKEN cDNA 4930527A07 gene Neighboring gene STARR-seq mESC enhancer starr_05309 Neighboring gene paired box 6 opposite strand 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of the gene encoding mouse reticulocalbin, a novel endoplasmic reticulum-resident Ca(2+)-binding protein with multiple EF-hand motifs. Ozawa M. J Biochem, 1995 Jul. PMID 8537305
    2. Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. Deng S, et al. Mol Oncol, 2023 Dec. PMID 37746742, Free PMC Article
    3. Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs. Ozawa M. J Biochem, 1995 May. PMID 8586628
    4. Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence. Ozawa M, et al. J Biol Chem, 1993 Jan 5. PMID 8416973
    5. Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. Merrick BA, et al. Electrophoresis, 1994 May. PMID 7523108

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells.
      Title: Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    reticulocalbin-1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009037.2 → NP_033063.1  reticulocalbin-1 precursor

      See identical proteins and their annotated locations for NP_033063.1

      Status: VALIDATED

      Source sequence(s)
      AK017494, AK133971, BB612908
      Consensus CDS
      CCDS16498.1
      UniProtKB/Swiss-Prot
      Q05186, Q3TVU3
      Related
      ENSMUSP00000006128.7, ENSMUST00000006128.7
      Conserved Domains (3) summary
      COG5126
      Location:62 → 232
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:204 → 267
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:166 → 224
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      105216293..105229664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05186.1 GenPept UniProtKB/Swiss-Prot:Q05186

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous