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    Tmem68 transmembrane protein 68 [ Mus musculus (house mouse) ]

    Gene ID: 72098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem68provided by MGI
    Official Full Name
    transmembrane protein 68provided by MGI
    Primary source
    MGI:MGI:1919348
    See related
    Ensembl:ENSMUSG00000028232 AllianceGenome:MGI:1919348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Diesl; MGAT/DGAT; 2010300G19Rik
    Summary
    Predicted to enable phospholipid:diacylglycerol acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system. Orthologous to human TMEM68 (transmembrane protein 68). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 9.6), whole brain E14.5 (RPKM 7.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem68 in Genome Data Viewer
    Location:
    4 A1; 4 1.98 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (3549041..3574853, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (3549041..3574867, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11787 Neighboring gene STARR-seq mESC enhancer starr_09413 Neighboring gene microRNA 3471-2 Neighboring gene trimethylguanosine synthase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4609 Neighboring gene STARR-positive B cell enhancer mm9_chr4:3574269-3574569 Neighboring gene STARR-positive B cell enhancer ABC_E6150 Neighboring gene RIKEN cDNA 2210414B05 gene Neighboring gene STARR-seq mESC enhancer starr_09415 Neighboring gene predicted gene, 42250

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of an alternative triglyceride biosynthesis pathway. McLelland GL, et al. Nature, 2023 Sep. PMID 37648867, Free PMC Article
    2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    3. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of an alternative triglyceride biosynthesis pathway.
      Title: Identification of an alternative triglyceride biosynthesis pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phospholipid:diacylglycerol acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid:diacylglycerol acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DGAT1/2-independent enzyme synthesizing storage lipids
    Names
    2-acylglycerol/1,2-diacylglycerol O-acyltransferase
    monoacylglycerol/Diacylglycerol O-acyltransferase
    NP_082373.1
    XP_006538332.1
    XP_030109665.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028097.4 → NP_082373.1  DGAT1/2-independent enzyme synthesizing storage lipids

      See identical proteins and their annotated locations for NP_082373.1

      Status: VALIDATED

      Source sequence(s)
      AK048210, AK084881, AL732617
      Consensus CDS
      CCDS17937.1
      UniProtKB/Swiss-Prot
      Q3UGT4, Q8BTV3, Q9D850
      Related
      ENSMUSP00000029891.6, ENSMUST00000029891.12
      Conserved Domains (2) summary
      cd07987
      Location:103 → 309
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like
      COG0204
      Location:58 → 303
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

    RNA

    1. NR_149728.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK048210, AK084881, AK162563, AL732617
      Related
      ENSMUST00000154922.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      3549041..3574853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538269.5 → XP_006538332.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

      See identical proteins and their annotated locations for XP_006538332.1

      Conserved Domains (1) summary
      cd07987
      Location:1 → 195
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    2. XM_030253805.2 → XP_030109665.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

      Conserved Domains (1) summary
      cd07987
      Location:1 → 195
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    RNA

    1. XR_001784202.3 RNA Sequence

    2. XR_004941966.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D850.1 GenPept UniProtKB/Swiss-Prot:Q9D850

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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