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    Agbl1 ATP/GTP binding protein-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 244071, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agbl1provided by MGI
    Official Full Name
    ATP/GTP binding protein-like 1provided by MGI
    Primary source
    MGI:MGI:3646469
    See related
    Ensembl:ENSMUSG00000025754 AllianceGenome:MGI:3646469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccp4; Nna1-l1; EG244071; D430020F16
    Summary
    Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in C-terminal protein deglutamylation and protein side chain deglutamylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to human AGBL1 (AGBL carboxypeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Agbl1 in Genome Data Viewer
    Location:
    7 D1; 7 43.87 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (75879311..76774446)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (76229591..77124698)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19235 Neighboring gene predicted gene, 51413 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:83373966-83374075 Neighboring gene predicted gene, 51518 Neighboring gene STARR-seq mESC enhancer starr_19236 Neighboring gene STARR-seq mESC enhancer starr_19237 Neighboring gene thymine DNA glycosylase pseudogene Neighboring gene VISTA enhancer mm1397 Neighboring gene predicted gene, 30774 Neighboring gene predicted gene, 33069 Neighboring gene STARR-seq mESC enhancer starr_19238 Neighboring gene STARR-seq mESC enhancer starr_19239 Neighboring gene STARR-seq mESC enhancer starr_19240 Neighboring gene STARR-seq mESC enhancer starr_19241 Neighboring gene STARR-seq mESC enhancer starr_19242 Neighboring gene STARR-seq mESC enhancer starr_19244 Neighboring gene STARR-seq mESC enhancer starr_19245 Neighboring gene STARR-seq mESC enhancer starr_19246 Neighboring gene proliferating cell nuclear antigen pseudogene Neighboring gene predicted gene, 23239

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Wang T, et al. Mol Cell Neurosci, 2006 Oct. PMID 16952463
    2. A novel subfamily of mouse cytosolic carboxypeptidases. Kalinina E, et al. FASEB J, 2007 Mar. PMID 17244818
    3. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Liu B, et al. Nat Commun, 2017 Aug 10. PMID 28794449, Free PMC Article
    4. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Tort O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103237, Free PMC Article
    5. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Xia P, et al. Nat Immunol, 2016 Apr. PMID 26829768

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallocarboxypeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metallocarboxypeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C-terminal protein deglutamylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in C-terminal protein deglutamylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein side chain deglutamylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein side chain deglutamylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic carboxypeptidase 4
    Names
    protein deglutamylase CCP4
    NP_001186153.1
    XP_017177740.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199224.2 → NP_001186153.1  cytosolic carboxypeptidase 4

      See identical proteins and their annotated locations for NP_001186153.1

      Status: VALIDATED

      Source sequence(s)
      AC093474, AC115830, AC121812, AC121971, AC123792, AC132333, AC154104
      Consensus CDS
      CCDS85321.1
      UniProtKB/Swiss-Prot
      Q09M05, Q8C768
      UniProtKB/TrEMBL
      D3Z1M2
      Related
      ENSMUSP00000119721.3, ENSMUST00000156166.8
      Conserved Domains (1) summary
      cl11393
      Location:742 → 1018
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      75879311..76774446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322251.2 → XP_017177740.1  cytosolic carboxypeptidase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q09M05, Q8C768
      Conserved Domains (2) summary
      cd06906
      Location:753 → 1018
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:595 → 729
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    RNA

    1. XR_004934099.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172902.2: Suppressed sequence

      Description
      NM_172902.2: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09M05.3 GenPept UniProtKB/Swiss-Prot:Q09M05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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