Mir483 microRNA 483 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir483provided by MGI
Official Full Name: microRNA 483provided by MGI
Primary source: MGI:MGI:3619420
See related: Ensembl:ENSMUSG00000070140 miRBase:MI0003484; AllianceGenome:MGI:3619420
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn483; mir-483; mmu-mir-483
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 7 F5; 7 87.99 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142208661..142208733, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (142654924..142654996, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice.
Title: Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice.
Obesity-induced upregulation of miR-483-5p impairs the function and identity of pancreatic beta-cells.
Title: Obesity-induced upregulation of miR-483-5p impairs the function and identity of pancreatic β-cells.
miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala.
Title: miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala.
microRNA-483 Protects Pancreatic beta-Cells by Targeting ALDH1A3.
Title: microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3.
HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis.
Title: HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis.
the present study suggested that miR4833p promoted osteogenic differentiation of BMSCs by targeting STAT1, and miR4833 prepresent a potential therapeutic target for agerelated bone loss.
Title: miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1.
mTORC1 controls the histone deacetylase 4-dependent expression of miR-483-5p to stimulate chondrocyte hypertrophy
Title: Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression.
The overexpression of miR4833p promoted apoptosis, increased caspase3 and 9 activity levels, and induced the protein expression of Bax/Bcl2 in the acute myocardial infarction model.
Title: miR-483-3p regulates acute myocardial infarction by transcriptionally repressing insulin growth factor 1 expression.
Transfection of hADSCs with inhibitors of miR-483-5p led to a significant increase of ERK1/2 phosphorylation in the nucleus.
Title: miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.
miR-483 has opposite effects in alpha- and beta-pancreatic cells by targeting SOCS3.
Title: Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

Igf2 (e-PCR), detects polymorphism
- UniSTS:532252

Igf2 (e-PCR), detects polymorphism
- UniSTS:143481

UniSTS:276141 (e-PCR)
- UniSTS:276141

Igf2 (e-PCR), detects polymorphism
- UniSTS:276141

PMC309645P4 (e-PCR)
- UniSTS:272603

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within ossification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxygen levels	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.