NUP60 FG-nucleoporin NUP60 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NUP60
Official Full Name: FG-nucleoporin NUP60
Primary source: SGD:S000000063
Locus tag: YAR002W
See related: AllianceGenome:SGD:S000000063; FungiDB:YAR002W; VEuPathDB:YAR002W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phospholipid binding activity. A structural constituent of nuclear pore. Involved in several processes, including nucleocytoplasmic transport; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; and silent mating-type cassette heterochromatin formation. Located in cytosol and nucleus. Part of nuclear pore central transport channel and nuclear pore nuclear basket. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NUP60 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (152257..153876)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization.
Title: Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization.
The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae.
Title: The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae.
While Nup60 is the unique target of genotoxic stress within the nuclear basket that probably belongs to the SUMO-mediated DNA damage response pathway, both Nup2 and Nup60 show a dramatic increase in SUMOylation upon osmotic stress, with Nup2 SUMOylation being enhanced in Nup60 SUMO-deficient mutant yeast strains.
Title: SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses.
high levels of the Nup1/Nup60 amphipathic helices cause deformation of the yeast nuclear membrane
Title: Nuclear pore basket proteins are tethered to the nuclear envelope and can regulate membrane curvature.
Data shsow that loss of Ncs2, Nup60, or Pom152 led to an impaired ability to increase SPB size during metaphase arrest, implicating these proteins in SPB component assembly.
Title: Identification of Saccharomyces cerevisiae spindle pole body remodeling factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	IGI Inferred from Genetic Interaction more info	PubMed
enables structural constituent of nuclear pore	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of nuclear pore	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus in response to heat stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus in response to heat stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein desumoylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere tethering at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere tethering at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FG-nucleoporin NUP60

NP_009401.1

FG-nucleoporin component of the nuclear pore complex central core; direct role in nucleocytoplasmic transport and maintenance of the NPC permeability barrier; role in gene tethering at the nuclear periphery; short linear motifs connect Mlp1p and the Y-complex via Nup85p to facilitate nuclear basket docking onto the core of the NPC; Cdc5p-mediated phosphorylation leads to detachment and reattachment of the basket during meiosis; both NUP1 and NUP60 are human NUP153 homologs