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    CSG2 mannosylinositol phosphorylceramide synthase regulatory subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSG2
    Official Full Name
    mannosylinositol phosphorylceramide synthase regulatory subunit
    Primary source
    SGD:S000000240
    Locus tag
    YBR036C
    See related
    AllianceGenome:SGD:S000000240; FungiDB:YBR036C; VEuPathDB:YBR036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS2
    Summary
    Enables enzyme regulator activity and intracellularly gated calcium channel activity. Involved in endoplasmic reticulum calcium ion homeostasis; glycosphingolipid biosynthetic process; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Located in endoplasmic reticulum and fungal-type vacuole. Is active in endoplasmic reticulum membrane. Used to study Charcot-Marie-Tooth disease. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CSG2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (309081..310313, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cu-binding protein SCO1 Neighboring gene chitin synthase CHS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae. Beeler T, et al. J Biol Chem, 1994 Mar 11. PMID 8125941
    2. Mutations in GDAP1 Influence Structure and Function of the Trans-Golgi Network. Binięda K, et al. Int J Mol Sci, 2021 Jan 18. PMID 33477664, Free PMC Article
    3. The CLS2 gene encodes a protein with multiple membrane-spanning domains that is important Ca2+ tolerance in yeast. Takita Y, et al. Mol Gen Genet, 1995 Feb 6. PMID 7854312
    4. Pathogenic Effect of GDAP1 Gene Mutations in a Yeast Model. Rzepnikowska W, et al. Genes (Basel), 2020 Mar 14. PMID 32183277, Free PMC Article
    5. Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain. Dunn TM, et al. Yeast, 1998 Mar 15. PMID 9559540

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy.
      Title: The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy.
    2. Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
      Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables intracellularly gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannosylinositol phosphorylceramide synthase regulatory subunit
    NP_009592.1
    • Calcium release channel involved in ER calcium homeostasis; integrates ER calcium release with the regulation of sphingolipid metabolism and autophagy; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; endoplasmic reticulum membrane protein; contains 10 transmembrane domains and a potential Ca2+ EF-hand motif; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      309081..310313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178384.1 → NP_009592.1  TPA: mannosylinositol phosphorylceramide synthase regulatory subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ36, P35206
      UniProtKB/TrEMBL
      A6ZKY0, B3LNA9, B5VE02, C7GXX6, D3UED2, N1P9C8
      Conserved Domains (1) summary
      pfam16965
      Location:1 → 403
      CSG2; Ceramide synthase regulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35206.2

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