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    ZNF695 zinc finger protein 695 [ Homo sapiens (human) ]

    Gene ID: 57116, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF695provided by HGNC
    Official Full Name
    zinc finger protein 695provided by HGNC
    Primary source
    HGNC:HGNC:30954
    See related
    Ensembl:ENSG00000197472 MIM:616348; AllianceGenome:HGNC:30954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SBZF3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See ZNF695 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (246945546..247008057, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (246377209..246439658, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247108848..247171359, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246957595-246958236 Neighboring gene long intergenic non-protein coding RNA 1341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2861 Neighboring gene MPRA-validated peak823 silencer Neighboring gene MPRA-validated peak824 silencer Neighboring gene AT-hook containing transcription factor 1 Neighboring gene MPRA-validated peak825 silencer Neighboring gene MPRA-validated peak826 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2863 Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2865 Neighboring gene Sharpr-MPRA regulatory region 11618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:247165417-247165917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2041 Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene zinc finger protein 670

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy. Takahashi T, et al. J Cancer Res Clin Oncol, 2015 Mar. PMID 25273507
    2. Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer. Juárez-Méndez S, et al. J Ovarian Res, 2013 Sep 5. PMID 24007497, Free PMC Article
    3. Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm. Chen J, et al. Front Immunol, 2022. PMID 36311753, Free PMC Article
    4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.
      Title: Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.
    2. ZNF695 methylation was associated with the response to definitive chemoradiotherapy in esophageal squamous cell carcinoma.
      Title: ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF670-ZNF695

    Readthrough gene: ZNF670-ZNF695, Included gene: ZNF670

    Homology

    Clone Names

    • MGC61907

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 695
    Names
    zinc finger protein SBZF3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204221.2 → NP_001191150.2  zinc finger protein 695 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC113174, AL512637
      Consensus CDS
      CCDS55694.1
      Related
      ENSP00000429736.1, ENST00000487338.6
      Conserved Domains (1) summary
      smart00349
      Location:4 → 76
      KRAB; krueppel associated box

    2. NM_020394.5 → NP_065127.5  zinc finger protein 695 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL512637
      Consensus CDS
      CCDS44344.1
      UniProtKB/Swiss-Prot
      Q5T0N9, Q5T0P1, Q5T0P3, Q7Z2W8, Q7Z648, Q8IW36
      Related
      ENSP00000341236.7, ENST00000339986.8
      Conserved Domains (3) summary
      smart00349
      Location:4 → 76
      KRAB; krueppel associated box
      COG5048
      Location:148 → 515
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:354 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_037892.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains alternate exon structure in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC113174, AL512637
      Related
      ENST00000366504.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      246945546..247008057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      246377209..246439658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IW36.4 GenPept UniProtKB/Swiss-Prot:Q8IW36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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